The naturally occurring polyamines, spermidine, spermine, and their precursor putrescine,
play indispensible roles in both prokaryotic and eukaryotic cells, from basic DNA synthesis …

To identify mechanisms of anabolic androgen action in muscle, we generated male and
female genomic androgen receptor (AR) knockout (ARKO) mice, and characterized muscle …

Androgens increase both the size and strength of skeletal muscle via diverse mechanisms.
The aim of this review is to discuss the different cellular targets of androgens in skeletal …

Myoblast differentiation into multinuclear myotubes implies the slow-down of their
proliferative drive and the expression of myogenin, an early marker of myogenic …

The aim of this study is to determine if the Odc1 gene, which encodes ornithine
decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, is directly …

The polyamines putrescine, spermidine and spermine represent a group of naturally
occurring compounds exerting a bewildering number of biological effects, yet despite …

Polyamines have been shown to be absolutely required for protein synthesis and cell
growth. The serine/threonine kinase, the mechanistic target of rapamycin complex 1 …

Polyamines are polycationic molecules that contain two or more amino groups (–NH3+) and
are present in all eukaryotic and prokaryotic cells. Polyamines are synthesized from …

Background Physical exercise and testosterone administration result in a series of adaptive
anabolic phenomena in the skeletal muscle. The role of polyamines in these processes has …

Transgenic mice expressing proteins altering polyamine levels in a tissue-specific manner
have considerable promise for evaluation of the roles of polyamines in normal, hypertrophic …