Glycosyltransferases as biocatalysts
MM Palcic - Current opinion in chemical biology, 2011 - Elsevier
Glycosyltransferases are useful synthetic tools for the preparation of natural
oligosaccharides, glycoconjugates and their analogues. High expression levels of …
oligosaccharides, glycoconjugates and their analogues. High expression levels of …
Synthesis and modifications of carbohydrates, using biotransformations
AM Daines, BA Maltman, SL Flitsch - Current Opinion in Chemical Biology, 2004 - Elsevier
Enzymes continue to be used as important catalysts, for the generation of rare and
'unnatural'monosaccharides and for the selective formation of glycosidic linkages. Multi …
'unnatural'monosaccharides and for the selective formation of glycosidic linkages. Multi …
Teaching old enzymes new tricks: engineering and evolution of glycosidases and glycosyl transferases for improved glycoside synthesis
FA Shaikh, SG Withers - Biochemistry and Cell Biology, 2008 - cdnsciencepub.com
The therapeutic potential of glycosides has made them an attractive target for drug
development. The biological extraction and chemical synthesis of these molecules is often …
development. The biological extraction and chemical synthesis of these molecules is often …
Oligosaccharide synthesis by glycosynthases
Oligosaccharide synthesis is becoming increasingly important to the pharmaceutical
industry because these biomolecules have potential application as therapeutics. Enzymatic …
industry because these biomolecules have potential application as therapeutics. Enzymatic …
Glycosyltransferase-catalyzed synthesis of non-natural oligosaccharides
R Öhrlein - Biocatalysis-From Discovery to Application, 1999 - Springer
Enzymes are indispensable tools in modern organic synthesis. Recent progress in cloning
techniques, microbiology and protein purification supply an ever growing number and …
techniques, microbiology and protein purification supply an ever growing number and …
New approaches to enzymatic glycoside synthesis through directed evolution
R Kittl, SG Withers - Carbohydrate research, 2010 - Elsevier
The expanding field of glycobiology requires tools for the synthesis of structurally defined
oligosaccharides and glycoconjugates, while any potential therapeutic applications of sugar …
oligosaccharides and glycoconjugates, while any potential therapeutic applications of sugar …
Enzymatic glycosyl transfer: mechanisms and applications
T Desmet, W Soetaert - Biocatalysis and Biotransformation, 2011 - Taylor & Francis
Glycosylated compounds have numerous applications in the food, pharmaceutical and
personal care industries. Their synthesis is, however, far from trivial. Because chemical …
personal care industries. Their synthesis is, however, far from trivial. Because chemical …
Reprint of: Advanced glycosidases as ingenious biosynthetic instruments
Z Mészáros, P Nekvasilová, P Bojarová, V Křen… - Biotechnology …, 2021 - Elsevier
Until recently, glycosidases, naturally hydrolyzing carbohydrate-active enzymes, have found
few synthetic applications in industry, being primarily used for cleaving unwanted …
few synthetic applications in industry, being primarily used for cleaving unwanted …
Chemical transformations employing glycosyltransferases
U Gambert, J Thiem - Glycoscience Synthesis of Oligosaccharides and …, 2008 - Springer
Abstract Early on, Emil Fischer proposed the use and technological application of enzymes
in natural product chemistry, in particular in peptide and carbohydrate synthesis. After …
in natural product chemistry, in particular in peptide and carbohydrate synthesis. After …
Glycosidases and glycosyl transferases in glycoside and oligosaccharide synthesis
DHG Crout, G Vic - Current opinion in chemical biology, 1998 - Elsevier
Remarkable advances in glycobiology in recent years have stimulated a resurgence of
interest in carbohydrate chemistry. The challenge of producing the complex glycosides and …
interest in carbohydrate chemistry. The challenge of producing the complex glycosides and …