Repeated assessment of anxiety-like behavior in mice: a new tool with increasedreliability and consistency
Anxiety is a debilitating disorder with high prevalence and co-morbidity across multiple
psychiatric diseases. Evidence from both clinical and preclinical studies suggest that the …
psychiatric diseases. Evidence from both clinical and preclinical studies suggest that the …
Residual avoidance: a new, consistent and repeatable readout of chronic stress-induced conflict anxiety reversible by antidepressant treatment
Stress-related illnesses such as major depressive and anxiety disorders are characterized
by maladaptive responses to stressful life events. Chronic stress-based animal models have …
by maladaptive responses to stressful life events. Chronic stress-based animal models have …
Improving anxiety research: novel approach to reveal trait anxiety through summary measures of multiple states
The reliability and validity of preclinical anxiety testing is essential for translational research
outcomes. However, widely-used anxiety tests lack inter-test correlations and have …
outcomes. However, widely-used anxiety tests lack inter-test correlations and have …
[PDF][PDF] Gyula Y Balla, Levente Kontra, Zsófia Eckert, Zsolt Borhegyi, Éva Mikics* equal contribution corresponding authors
The reliability and validity of preclinical anxiety testing is essential for translational research
outcomes. However, widely-used anxiety tests lack inter-test correlations and have …
outcomes. However, widely-used anxiety tests lack inter-test correlations and have …
[HTML][HTML] Unpredictable Mixed-Valence Outcomes Induce a Chronic and Reversible Generalized Anxiety-like Phenotype in Male Mice
DW Crawford, KR Patel, A Swiecka, J Bond… - … Psychiatry Global Open …, 2024 - Elsevier
Background Clinical anxiety is a generalized state characterized by feelings of
apprehensive expectation and is distinct from momentary responses such as fear or stress …
apprehensive expectation and is distinct from momentary responses such as fear or stress …
[HTML][HTML] Animal Models of Anxiety and Depression: Exploring the Underlying Mechanisms of Sex Differences
Anxiety and depression carry a significant burden and disproportionally affect more women
than men (Balta et al., 2019). Moreover, men and women differ in symptomatology and …
than men (Balta et al., 2019). Moreover, men and women differ in symptomatology and …
Co-expression network of mRNAs and lncRNAs regulated by stress-linked behavioral assays
J Zhang, M Xue, Y Mei, Z Li, Z Ceng, Y Li, Y Zhang… - …, 2020 - Springer
Rationale Mood-related behavioral assays, designed typically on rodents' natural aversion
to certain threats, are useful in studying the mechanisms of mood and in discovering …
to certain threats, are useful in studying the mechanisms of mood and in discovering …
Punishment Risk Task: Monitoring anxiogenic states during goal directed actions in mice
Canonical preclinical studies of anxiety-related behavioral states have been critical to
developing mechanistic insights and therapeutics for neuropsychiatric disorders. Most of …
developing mechanistic insights and therapeutics for neuropsychiatric disorders. Most of …
Reliability of mouse behavioural tests of anxiety: a systematic review and meta-analysis on the effects of anxiolytics
M Rosso, R Wirz, AV Loretan, NA Sutter… - BioRxiv, 2021 - biorxiv.org
Animal research on anxiety and anxiety disorders relies on valid animal models of anxiety.
However, the validity of widely used rodent behavioural tests of anxiety has repeatedly been …
However, the validity of widely used rodent behavioural tests of anxiety has repeatedly been …
Modeling anxiety in healthy humans: a key intermediate bridge between basic and clinical sciences
Animal models of anxiety disorders are important for elucidating neurobiological defense
mechanisms. However, animal models are limited when it comes to understanding the more …
mechanisms. However, animal models are limited when it comes to understanding the more …