Recent developments of introducing stratified medicine/personal health care have led to an
increased demand for specific biomarkers. However, despite the myriads of biomarkers …

The unprecedented progress of medical therapy over the last few decades is associated
with the advancement of understanding of molecular mechanisms of human diseases …

EDITORIAL| Booth we have only scratched the surface. However, before all of these ideas
can be tested, before they can be used in clinical practice, we need to be able to measure …

Failure begins in discovery While acknowledging that most flawed biomarker studies may
involve multiple, cascading errors [9, 10], the penalty for mistakes in early discovery …

The last decade has seen an extraordinary amount of effort devoted in biomedical research
to the field of biomarkers. There have been some notable successes with novel markers …

The recent advances in genomics (gene expression arrays and SNPs), proteomics (protein
expression using mass spectrometry or antibody arrays) opened the door for biomedical …

Medicine (CCLM) contains an editorial by Rifai and colleagues [2] that was recently
published in Clinical Chemistry dealing with the current predicaments and providing the …

Importance of the field: Recently, there has been growing evidence for the concept of
personalized medicine as the implementation of genomic and molecular information in the …

Nevertheless, one should not underestimate the difficulty of finding and validating the right
biomarkers. It is a very complex endeavor involving multiple disciplines and heterogeneous …

BACKGROUND The large, expanding literature on biomarkers is characterized by almost
ubiquitous significant results, with claims about the potential importance, but few of these …