Background Estimation of the risk of adverse long‐term outcomes such as second malignant
neoplasms and infertility often requires reproducible quantification of exposures. The …

Background Few data define the dose-specific relation between alkylating agent exposure
and semen variables in adult survivors of childhood cancer. We undertook this study to test …

Background The effect of many contemporary chemotherapeutic drugs on pregnancy and
livebirth is not well established. We aimed to establish the effects of these drugs on …

Cancer risk assessment methods currently assume that children and adults are equally
susceptible to exposure to chemicals. We reviewed available scientific literature to …

PURPOSE Therapeutic radiation in childhood cancer has decreased over time with a
concomitant increase in chemotherapy. Limited data exist on chemotherapy-associated …

Purpose Childhood cancer survivors (CCSs) are at increased risk for subsequent malignant
neoplasms (SMNs). We evaluated the long-term risk of SMNs in a well-characterized cohort …

The Pediatric Hodgkin Lym phoma Consortium, which in cludes St. Jude Children's
Research Hospital, Stanford University, Dana–Farber Cancer Institute/Bos ton Children's …

The Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of
Childhood, Adolescent, and Young Adult Cancers are risk-based, exposure-related clinical …

In standard risk assessment methods for carcinogenic or noncarcinogenic chemicals,
quantitative methods for evaluating interindividual variability are not explicitly considered …

The purpose of the Benchmark Dose Workshop was to assess the feasibility and
implications of replacing the no observed adverse effect level (NOAEL) with a benchmark …