Amyotrophic lateral sclerosis (ALS; motor neuron disease) is a relentlessly progressive
disorder. After half a century of trials, only one drug with modest disease-modifying potency …

Diffusion magnetic resonance (MR) imaging is evolving into a potent tool in the examination
of the central nervous system. Although it is often used for the detection of acute ischemia …

We collected MRI diffusion tensor imaging data from 80 younger (20–32 years) and 63 older
(60–71 years) healthy adults. Tract-based spatial statistics (TBSS) analysis revealed that …

Objective: While the hallmark of amyotrophic lateral sclerosis (ALS) is corticospinal tract in
combination with lower motor neuron degeneration, the clinical involvement of both …

Degeneration of cerebral white matter (WM), or structural disconnection, is one of the major
neural mechanisms driving age-related decline in cognitive functions, such as processing …

The role of diffusion-weighted magnetic resonance imaging (DWI) to differentiate breast
lesions in vivo was evaluated. Sixty women (mean age, 53 years) with 81 breast lesions …

Amyotrophic lateral sclerosis (ALS) is characterized phenotypically by progressive
weakness and neuropathologically by loss of motor neurons. Phenotypically, there is …

Background and purpose Brain radiotherapy is limited in part by damage to white matter,
contributing to neurocognitive decline. We utilized diffusion tensor imaging (DTI) with …

Cerebral palsy due to perinatal injury to cerebral white matter is usually not caused by
genetic mutations, but by ischemia and/or inflammation. Here, we describe an autosomal …

In motor neuron disease, the focus of therapy is to prevent or slow neuronal degeneration
with neuroprotective pharmacological agents; early diagnosis and treatment are thus …