Clinical measures of bulbar dysfunction in ALS

Y Yunusova, EK Plowman, JR Green, C Barnett… - Frontiers in …, 2019 - frontiersin.org
Bulbar impairment represents a hallmark feature of Amyotrophic Lateral Sclerosis (ALS) that
significantly impacts survival and quality of life. Speech and swallowing dysfunction are key …

Spinal cord imaging in amyotrophic lateral sclerosis: historical concepts—novel techniques

MM El Mendili, G Querin, P Bede, PF Pradat - Frontiers in neurology, 2019 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is the most common adult onset motor neuron disease
with no effective disease modifying therapies at present. Spinal cord degeneration is a …

Significance of CSF NfL and tau in ALS

S Schreiber, N Spotorno, F Schreiber… - Journal of …, 2018 - Springer
Cerebrospinal fluid (CSF) neurofilament light chain (NfL) has emerged as putative
diagnostic biomarker in amyotrophic lateral sclerosis (ALS), but it remains a matter of …

Precentral degeneration and cerebellar compensation in amyotrophic lateral sclerosis: a multimodal MRI analysis

T Qiu, Y Zhang, X Tang, X Liu, Y Wang… - Human Brain …, 2019 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a progressive and intractable neurodegenerative
disease of human motor system characterized by progressive muscular weakness and …

Usefulness of diffusion tensor imaging findings as biomarkers for amyotrophic lateral sclerosis

SH Baek, J Park, YH Kim, HY Seok, KW Oh, HJ Kim… - Scientific reports, 2020 - nature.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. However, no reliable
biomarkers have been identified to represent the clinical status. This study aimed to …

Feature selection from magnetic resonance imaging data in ALS: a systematic review

TD Kocar, HP Mueller, AC Ludolph… - … advances in chronic …, 2021 - journals.sagepub.com
Background: With the advances in neuroimaging in amyotrophic lateral sclerosis (ALS), it
has been speculated that multiparametric magnetic resonance imaging (MRI) is capable to …

Lower and upper motor neuron involvement and their impact on disease prognosis in amyotrophic lateral sclerosis

MN Zakharova, AA Abramova - Neural regeneration research, 2022 - journals.lww.com
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by
progressive muscle wasting, breathing and swallowing difficulties resulting in patient's death …

Unveiling early cortical and subcortical neuronal degeneration in ALS mice by ultra-high field diffusion MRI

RG Gatto, M Amin, A Finkielsztein… - … Lateral Sclerosis and …, 2019 - Taylor & Francis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease primarily characterized
by the progressive impairment of motor functions. However, a significant portion of affected …

[HTML][HTML] Patterns of grey and white matter changes differ between bulbar and limb onset amyotrophic lateral sclerosis

R Steinbach, T Prell, N Gaur, A Roediger, C Gaser… - NeuroImage: Clinical, 2021 - Elsevier
Abstract Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease
that is characterized by a high heterogeneity in patients' disease course. Patients with bulbar …

[HTML][HTML] Sex biology in amyotrophic lateral sclerosis

A Zamani, E Thomas, DK Wright - Ageing Research Reviews, 2024 - Elsevier
Although sex differences in amyotrophic lateral sclerosis (ALS) have not been studied
systematically, numerous clinical and preclinical studies have shown sex to be influential in …