Predicting transporter-based drug clearance (CL) and tissue concentrations (TC) in humans
is important to reduce the risk of failure during drug development. In addition, when …

The role of membrane transporters on pharmacokinetics (PKs), drug–drug interactions
(DDIs), pharmacodynamics (PDs), and toxicity of drugs has been broadly recognized …

Abstract Background and Objective More than half of all drugs are still prescribed off-label to
children. Pharmacokinetic (PK) data are needed to support off-label dosing, however for …

Drug development for the central nervous system (CNS) is a complex endeavour with low
success rates, as the structural complexity of the brain and specifically the blood-brain …

This paper is the forty-fourth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Rational drug use in special populations is a clinical problem that doctors and pharma-cists
must consider seriously. Neonates are the most physiologically immature and vulnerable to …

Providing effective acute pain management to hospitalized children can help improve
outcomes, decrease length of stay, and increase patient and parental satisfaction. Error …

Variation in the efficacy and safety of central nervous system drugs between humans and
rodents can be explained by physiological differences between species. An important factor …

Neuropathic pain is due to an injury or disease of the somatosensory nervous system, which
accounts for a significant economical and health burden to society. Due to poor …

Abstract Morphine and morphine-6-glucuronide (M6G) produce central nervous system
(CNS) effects by activating mu-opioid receptors, while naloxone is used mainly for the …