Frontotemporal pathology in motor neuron disease phenotypes: Insights from neuroimaging
MC McKenna, P Corcia, P Couratier, WF Siah… - Frontiers in …, 2021 - frontiersin.org
Frontotemporal involvement has been extensively investigated in amyotrophic lateral
sclerosis (ALS) but remains relatively poorly characterized in other motor neuron disease …
sclerosis (ALS) but remains relatively poorly characterized in other motor neuron disease …
The presymptomatic phase of amyotrophic lateral sclerosis: are we merely scratching the surface?
RH Chipika, WF Siah, MC McKenna, S Li Hi Shing… - Journal of …, 2020 - Springer
Presymptomatic studies in ALS have consistently captured considerable disease burden
long before symptom manifestation and contributed important academic insights. With the …
long before symptom manifestation and contributed important academic insights. With the …
Pathological neural networks and artificial neural networks in ALS: diagnostic classification based on pathognomonic neuroimaging features
P Bede, A Murad, O Hardiman - Journal of neurology, 2021 - Springer
The description of group-level, genotype-and phenotype-associated imaging traits is
academically important, but the practical demands of clinical neurology centre on the …
academically important, but the practical demands of clinical neurology centre on the …
Phenotypic categorisation of individual subjects with motor neuron disease based on radiological disease burden patterns: a machine-learning approach
Motor neuron disease is an umbrella term encompassing a multitude of clinically
heterogeneous phenotypes. The early and accurate categorisation of patients is hugely …
heterogeneous phenotypes. The early and accurate categorisation of patients is hugely …
Not a benign motor neuron disease: longitudinal imaging captures relentless motor connectome disintegration in primary lateral sclerosis
M Tahedl, EL Tan, SLH Shing… - European Journal of …, 2023 - Wiley Online Library
Background and purpose Primary lateral sclerosis (PLS) is a progressive upper motor
neuron disorder associated with considerable clinical disability. Symptoms are typically …
neuron disorder associated with considerable clinical disability. Symptoms are typically …
Brainstem–cortex disconnection in amyotrophic lateral sclerosis: bulbar impairment, genotype associations, asymptomatic changes and biomarker opportunities
Background Bulbar dysfunction is a cardinal feature of ALS with important quality of life and
management implications. The objective of this study is the longitudinal evaluation of a large …
management implications. The objective of this study is the longitudinal evaluation of a large …
Propagation patterns in motor neuron diseases: Individual and phenotype-associated disease-burden trajectories across the UMN-LMN spectrum of MNDs
Motor neuron diseases encompass a divergent group of conditions with considerable
differences in clinical manifestations, survival, and genetic vulnerability. One of the key …
differences in clinical manifestations, survival, and genetic vulnerability. One of the key …
Neuroimaging in primary lateral sclerosis
Increased interest in the underlying pathogenesis of primary lateral sclerosis (PLS) and its
relationship to amyotrophic lateral sclerosis (ALS) has corresponded to a growing number of …
relationship to amyotrophic lateral sclerosis (ALS) has corresponded to a growing number of …
Feature selection from magnetic resonance imaging data in ALS: a systematic review
TD Kocar, HP Mueller, AC Ludolph… - … advances in chronic …, 2021 - journals.sagepub.com
Background: With the advances in neuroimaging in amyotrophic lateral sclerosis (ALS), it
has been speculated that multiparametric magnetic resonance imaging (MRI) is capable to …
has been speculated that multiparametric magnetic resonance imaging (MRI) is capable to …
Primary lateral sclerosis: clinical, radiological and molecular features
P Bede, PF Pradat, J Lope, P Vourc'h, H Blasco… - Revue …, 2022 - Elsevier
Abstract Primary Lateral Sclerosis (PLS) is an uncommon motor neuron disorder. Despite
the well-recognisable constellation of clinical manifestations, the initial diagnosis can be …
the well-recognisable constellation of clinical manifestations, the initial diagnosis can be …