Mechanisms and possible hepatoprotective effects of glucagon-like peptide-1 receptor agonists and other incretin receptor agonists in non-alcoholic fatty liver disease

G Targher, A Mantovani, CD Byrne - The lancet Gastroenterology & …, 2023 - thelancet.com
Summary Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic
polypeptide (GIP) are incretins that stimulate insulin secretion from pancreatic β cells in …

Obesity-induced and weight-loss-induced physiological factors affecting weight regain

MA van Baak, ECM Mariman - Nature Reviews Endocrinology, 2023 - nature.com
Weight regain after successful weight loss resulting from lifestyle interventions is a major
challenge in the management of overweight and obesity. Knowledge of the causal …

GDF15 promotes weight loss by enhancing energy expenditure in muscle

D Wang, LK Townsend, GJ DesOrmeaux, SM Frangos… - Nature, 2023 - nature.com
Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic
fatty liver disease and improving insulin sensitivity in people with type 2 diabetes. Despite its …

Mediators of amylin action in metabolic control

CN Boyle, Y Zheng, TA Lutz - Journal of clinical medicine, 2022 - mdpi.com
Amylin (also called islet amyloid polypeptide (IAPP)) is a pancreatic beta-cell hormone that
is co-secreted with insulin in response to nutrient stimuli. The last 35 years of intensive …

Antibody blockade of activin type II receptors preserves skeletal muscle mass and enhances fat loss during GLP-1 receptor agonism

E Nunn, N Jaiswal, M Gavin, K Uehara… - Molecular …, 2024 - Elsevier
Objective Glucagon-like peptide 1 (GLP-1) receptor agonists reduce food intake, producing
remarkable weight loss in overweight and obese individuals. While much of this weight loss …

Effect of drugs on nutritional status and drug–nutrition interactions in older patients

M Kuzuya - Geriatrics & Gerontology International, 2023 - Wiley Online Library
Older patients are prone to multimorbidity or related polypharmacy, which may cause
various adverse drug reactions (ADRs) and a high incidence of drug‐related health …

Lipid emulsion structure, digestion behavior, physiology, and health: a scoping review and future directions

E Dassoff, A Shireen, A Wright - Critical Reviews in Food Science …, 2023 - Taylor & Francis
Research investigating the effects of the food matrix on health is needed to untangle many
unresolved questions in nutritional science. Emulsion structure plays a fundamental role in …

Glucagon‐like peptide‐1/glucagon receptor agonism associates with reduced metabolic adaptation and higher fat oxidation: a randomized trial

KD Corbin, EA Carnero, TD Allerton, J Tillner… - …, 2023 - Wiley Online Library
Objective This study tested the hypothesis that treatment with the glucagon‐like peptide‐
1/glucagon receptor agonist SAR425899 would lead to a smaller decrease in sleeping …

Comparison of Efficacy of Fermented Garlic and Orlistat (Lipase Inhibitor) in Obesity Management Using an Experimental Rodent Model

M Javed, W Ahmed, A Khan, I Rabbani - Foods, 2023 - mdpi.com
Background: Black garlic, also known as fermented garlic, is a useful food that may have
therapeutic benefits. The aim of this study was to analyze the impact of fermented garlic and …

Phyllanthus emblica L. extract alleviates leptin resistance and lipid accumulation by inhibiting methylglyoxal production

YN Huang, SY Chen, JA Lin, IC Chiang, GC Yen - Food Bioscience, 2023 - Elsevier
Increasing leptin resistance and methylglyoxal (MG) levels have been observed in patients
with obesity, which is characterized by an imbalance in energy metabolism and abnormal fat …