Recent studies have demonstrated that neuroplasticity, such as synaptic plasticity and
neurogenesis, exists throughout the normal lifespan but declines with age and is …

An important part of the central nervous system (CNS), the cerebellum is involved in motor
control, learning, reflex adaptation, and cognition. Diminished cerebellar function results in …

Amyotrophic lateral sclerosis (ALS) is a fatal and incurable paralytic disorder caused by the
progressive death of upper and lower motoneurons. Although numerous strategies have …

Introduction Pseudobulbar affect (PBA) is a distressing symptom of a multitude of
neurological conditions affecting patients with a rage of neuroinflammatory, neurovascular …

Background Primary lateral sclerosis (PLS) is traditionally solely associated with progressive
upper motor neuron dysfunction manifesting in limb spasticity, gait impairment, bulbar …

Introduction Hereditary spastic paraplegias (HSP) include a clinically and genetically
heterogeneous group of conditions. Novel imaging modalities have been increasingly …

There is an ever growing literature on frontotemporal dysfunction in motor neuron diseases,
but the practical caveats of using imaging to evaluate extra-motor changes and linking …

Background: Motor neuron diseases (MNDs) are progressive neurodegenerative disorders
characterized by motor impairment and non-motor symptoms. The involvement of the …

Background Primary lateral sclerosis (PLS) is traditionally regarded as a pure upper motor
neuron disorder, but recent cases series have highlighted cognitive deficits in executive and …

The regular intake of diets high in saturated fat and sugars increases oxidative stress and
has been linked to cognitive decline and premature brain aging. The cerebellum is highly …