In the past two decades, structural and functional neuroimaging findings have greatly
modified longstanding notions regarding the pathophysiology of amyotrophic lateral …

Bulbar impairment represents a hallmark feature of Amyotrophic Lateral Sclerosis (ALS) that
significantly impacts survival and quality of life. Speech and swallowing dysfunction are key …

Amyotrophic lateral sclerosis (ALS) is now universally recognized as a complex multisystem
disorder with considerable extra-motor involvement. The neuropsychological manifestations …

Primary lateral sclerosis (PLS) has been traditionally viewed as a distinct upper motor
neuron condition (UMN) but is increasingly regarded as a sub-phenotype within the …

Background Primary lateral sclerosis is a progressive upper-motor-neuron disorder
associated with markedly longer survival than ALS. In contrast to ALS, the genetic …

Background: Cross-sectional imaging studies offer valuable pathological insights into the
neurodegenerative changes of amyotrophic lateral sclerosis. However, clinical trials urgently …

The past decade has seen tremendous efforts in biomarker discovery and validation for
neurodegenerative diseases. The source and type of biomarkers has continued to grow for …

Temporal lobe studies in motor neuron disease overwhelmingly focus on white matter
alterations and cortical grey matter atrophy. Reports on amygdala involvement are …

Background Amyotrophic lateral sclerosis (ALS) a highly heterogeneous neurodegenerative
condition. Accurate diagnostic, monitoring and prognostic biomarkers are urgently needed …

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease and is
clinically characterised by the death of corticospinal motor neurons (CSMNs), spinal and …