To determine longitudinal rates of cortical atrophy in classical Amyotrophic lateral sclerosis
(ALS) and ALS variants. Rates of cortical thinning were determined between 2 scans, 3–15 …

Background MRI studies reported that ALS patients with bulbar and spinal onset showed
focal cortical changes in corresponding regions of the motor homunculus. We evaluated the …

BACKGROUND AND PURPOSE: The previous studies described phenotype-associated
imaging findings in amyotrophic lateral sclerosis (ALS) with a prior categorization of patients …

Objectives Primary lateral sclerosis (PLS) is commonly considered as a motor neuron
disease (MND) variant which almost exclusively affects upper motor neurons (UMN). There …

Background Besides the defining involvement of upper and lower motor neurons, the
involvement of extramotor structures has been increasingly acknowledged in amyotrophic …

Therapeutic management and research in Amyotrophic Laterals Sclerosis (ALS) have been
limited by the substantial heterogeneity in progression and anatomical spread that are …

Primary lateral sclerosis (PLS) is a rare neurodegenerative disorder which causes the
selective deterioration of the upper motor neurons (UMNs), sparing the lower motor neuron …

Purpose To investigate the patterns of cortical thinning and white matter tract damage in
patients with lower motor neuron (LMN)–predominant disease compared with healthy …

Objective: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative process
affecting upper and lower motor neurons as well as non-motor systems. In this study …

Background Current observational studies indicate progressive brain atrophy is closely
associated with the clinical feature of amyotrophic lateral sclerosis. However, it is unclear …