MR imaging–based estimation of upper motor neuron density in patients with amyotrophic lateral sclerosis: a feasibility study

J Chen, V Kostenko, EP Pioro, BD Trapp - Radiology, 2018 - pubs.rsna.org
Purpose To determine if magnetic resonance (MR) imaging metrics can estimate primary
motor cortex (PMC) motor neuron (MN) density in patients with amyotrophic lateral sclerosis …

Dominant heterogeneity of upper and lower motor neuron degeneration to motor manifestation of involved region in amyotrophic lateral sclerosis

J Jin, F Hu, Q Zhang, Q Chen, H Li, X Qin, R Jia… - Scientific Reports, 2019 - nature.com
The aim of this study was to localize the anatomic distribution of upper motor neuron (UMN)
loss through examining cortical thickness at the clinical onset of amyotrophic lateral …

Imaging Biomarkers in Amyotrophic Lateral Sclerosis

LC Alberich, JF Vázquez-Costa, A Ten-Esteve… - … Translating Research to …, 2022 - Springer
Amyotrophic lateral sclerosis (ALS) is a group of heterogeneous disorders characterized by
degenerative changes in upper motor neurons within the motor cortex and/or lower motor …

Cortical thinning of motor and non-motor brain regions enables diagnosis of amyotrophic lateral sclerosis and supports distinction between upper-and lower …

S Ferrea, F Junker, M Korth, K Gruhn, T Grehl… - Biomedicines, 2021 - mdpi.com
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder clinically
characterized by muscle atrophy and progressive paralysis. In addition to the classical ALS …

Voxel-based morphometry in amyotrophic lateral sclerosis

IS Bakulin, RN Konovalov… - Journal of radiology …, 2019 - russianradiology.ru
Objective: to investigate changes in grey matter volume in patients with classical
amyotrophic lateral sclerosis (ALS) and lower motor neuron syndrome (LMNS) with voxel …

Clinically applicable quantitative magnetic resonance morphologic measurements of grey matter changes in the human brain

T Fu, X Kobeleva, P Bronzlik, P Nösel, M Dadak… - Brain Sciences, 2021 - mdpi.com
(1) Purpose: Quantitative magnetic resonance imaging (qMRI) measurements can be used
to sensitively estimate brain morphological alterations and may support clinical diagnosis of …

[HTML][HTML] Воксель-ориентированная морфометрия при боковом амиотрофическом склерозе

ИС Бакулин, РН Коновалов… - Вестник …, 2018 - cyberleninka.ru
Цель исследования–изучить изменения объема серого вещества (СВ) головного мозга
с помощью воксель-ориентированной морфометрии (ВОМ) у пациентов с классическим …

Mapping abnormality: Towards evaluating MRI scans for individualized diagnosis and validation of clinical course/progression in motor neuron disease

M Tahedl - 2022 - epub.uni-regensburg.de
The present dissertation proposes a standardized assessment tool for meaningful
interpretation of individual patients' MRI data which may be used to infer on atrophy (or …

Amiotrophic lateral sclerosis

AD Schweitzer, AJ Tsiouris - Hybrid PET/MR Neuroimaging: A …, 2022 - Springer
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of upper
and lower motor neurons. The traditional role of imaging in the diagnosis of ALS has been …

[PDF][PDF] Results: Cross-sectional analysis demonstrated individually variable states of cortical thinning, which was most pronounced in the ventral section of the …

AM Wirth, A Khomenko, D Baldaranov, I Kobor… - academia.edu
Objective: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative process
affecting upper and lower motor neurons as well as non-motor systems. In this study …