The aim of the current review is to summarise the present status of physiologically based
pharmacokinetic (PBPK) modelling and its applications in drug research, and thus serve as …

Abstract multiple peaking in the blood fluid concentration-time curve is a phenomenon
occasionally encountered in pharmacokinetics. When it occurs, it can create difficulties in the …

Knowledge of pharmacokinetics is critical to understanding the absorption, distribution,
metabolism, and excretion of drugs. It is therefore vital to those engaged in the discovery …

Generic physiologically-based models of pharmacokinetics were evaluated for early drug
discovery. Plasma profiles after intravenous and oral dosing were simulated in rat for 68 …

The aim of this study was to identify the tissue-plasma partition coefficients (Kp) needed for
an initial prediction of the volume of distribution at steady state (Vdss) of a drug in humans …

As pan of an overall program to develop a framework for evaluating the contribution of
structural and physicochemical properties to pharmacokinetics, the distribution kinetics of …

Physiologically‐based pharmacokinetic (PBPK) models represent drug kinetics in one or
more 'real'organs (and hence require submodels of organs/tissues) and they describe …

Abstract Background and Objective Fentanyl can mitigate the mother and newborn
complications resulting from labor pain. However, fentanyl shows a narrow therapeutic index …

The aim of this study was to predict the disposition of midazolam in individual surgical
patients by physiologically based pharmacokinetic (PBPK) modeling and explore the causes …

Background The influence of changes in the physiologic state of a patient on the disposition
of fentanyl and alfentanil is poorly understood. The aims of this study were to determine …