Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Abstract In 1959, Niels Lassen illustrated the cerebral autoregulation curve in the classic
review article entitled Cerebral Blood Flow and Oxygen Consumption in Man. This concept …

Human imaging studies have shown that spontaneous brain activity exhibits stereotypic
spatiotemporal reorganization in awake, conscious conditions with respect to minimally …

Neurological diseases are the foremost cause of disability and the second leading cause of
death worldwide. Owing to the special microenvironment of neural tissues and biological …

Pericytes have been implicated in various neuropathologies, yet little is known about their
function and signaling pathways in health. Here, we characterized calcium dynamics of …

Gut microbiota has implications in Central Nervous System (CNS) disorders. Our study
systematically identified preclinical studies aimed to investigate the possible gut microbiota …

Maintaining an adequate level of sedation and analgesia plays a key role in the
management of traumatic brain injury (TBI). To date, it is unclear which drug or combination …

Ischaemic or haemorrhagic perioperative stroke (that is, stroke occurring during or within 30
days following surgery) can be a devastating complication following surgery. Incidence is …

Importance Traumatic brain injury (TBI) is associated with persistent functional and cognitive
deficits, which may be susceptible to secondary insults. The implications of exposure to …

Hypothermia is defined as a decrease in body core temperature to below 35° C. In cardiac
surgery, four stages of hypothermia are distinguished: mild, moderate, deep, and profound …