Recommendations to address key recruitment challenges of Alzheimer's disease clinical trials

JB Langbaum, J Zissimopoulos, R Au… - Alzheimer's & …, 2023 - Wiley Online Library
Clinical trials for Alzheimer's disease (AD) are slower to enroll study participants, take longer
to complete, and are more expensive than trials in most other therapeutic areas. The …

It's more than language: Cultural adaptation of a proven dementia care intervention for Hispanic/Latino caregivers

LJ Parker, KA Marx, M Nkimbeng, E Johnson… - The …, 2023 - academic.oup.com
Abstract Although Hispanic/Latino older adults are at disproportionate and increased risk for
Alzheimer's disease and related dementias, few evidence-based supportive care …

Genetic associations between sleep traits and cognitive ageing outcomes in the Hispanic Community Health Study/Study of Latinos

Y Zhang, M Elgart, E Granot-Hershkovitz, H Wang… - …, 2023 - thelancet.com
Background Sleep phenotypes have been reported to be associated with cognitive ageing
outcomes. However, there is limited research using genetic variants as proxies for sleep …

A call to address structural barriers to Hispanic/Latino representation in clinical trials on Alzheimer's disease and related dementias: A micro‐meso‐macro perspective

MP Aranda, DX Marquez… - … Research & Clinical …, 2023 - Wiley Online Library
Introduction This perspective paper addresses the US Hispanic/Latino (herein, Latino)
experience with regards to a significant public health concern—the underrepresentation of …

Increasing engagement of Hispanics/Latinos in clinical trials on Alzheimer's disease and related dementias

DX Marquez, A Perez, JK Johnson… - … Research & Clinical …, 2022 - Wiley Online Library
Abstract Introduction Despite evidence that Hispanic/Latino populations are 1.5 times more
likely than non‐Latino Whites to develop Alzheimer's disease and related dementias …

Challenges and opportunities in conducting research with older adults with dementia during COVID‐19 and beyond

RK Sharma, A Teng, MG Asirot… - Journal of the …, 2022 - Wiley Online Library
Abstract The coronavirus disease 19 (COVID‐19) pandemic has created significant and new
challenges for the conduct of clinical research involving older adults with Alzheimer's …

Alzheimer's Disease and Alzheimer's Disease-Related Dementias in Hispanics: Identifying Influential Factors and Supporting Caregivers

P Rawat, U Sehar, J Bisht, AP Reddy… - Ageing Research Reviews, 2023 - Elsevier
Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRD) are the
primary public health concerns in the United States and around the globe. AD/ADRD are …

STAR-Caregivers Virtual Training and Follow-up: a cultural adaptation for Latino caregivers of people with dementia

M Ramirez, MC Duran, RB Penfold… - Translational …, 2023 - academic.oup.com
Abstract STAR-Caregivers Virtual Training and Follow-up (STAR-VTF) is an evidence-based
intervention that teaches family caregivers how to manage behavioral and psychological …

Rates of and factors associated with patient withdrawal of consent in cancer clinical trials

SL Hillman, A Jatoi, CA Strand, J Perlmutter… - JAMA …, 2023 - jamanetwork.com
Importance Patient withdrawal of consent from a cancer clinical trial is defined as a patient's
volitional cessation of participation in all matters related to a trial. It can undermine the trial's …

Addressing Cognitive Assessment Disparities Among Hispanic Adults: Adapting the MoCA-SA for Improved Accuracy and Accessibility Among Spanish-speakers

LM Piedra, J Iveniuk, MJK Howe… - The Journals of …, 2024 - academic.oup.com
Objectives Hispanic adults display a higher likelihood of early-stage cognitive decline than
their White counterparts yet receive fewer clinical diagnoses. This troubling trend highlights …