Spinal muscular atrophy (SMA) is a hereditary neurodegenerative disease with severity
ranging from progressive infantile paralysis and premature death (type I) to limited motor …

Ever since loss of survival motor neuron (SMN) protein was identified as the direct cause of
the childhood inherited neurodegenerative disorder spinal muscular atrophy, significant …

In vertebrates, motor control relies on cholinergic neurons in the spinal cord that have been
extensively studied over the past hundred years, yet the full heterogeneity of these neurons …

Almost every muscle contains muscle spindles. These delicate sensory receptors inform the
central nervous system (CNS) about changes in the length of individual muscles and the …

Spinal muscular atrophy (SMA) is a devastating motor neuron disease that predominantly
affects children and represents the most common cause of hereditary infant mortality. The …

Spinal muscular atrophy (SMA) is a devastating neuromuscular disorder characterized by
loss of motor neurons and muscle atrophy, generally presenting in childhood. SMA is …

Genetic alterations impacting ubiquitously expressed proteins involved in RNA metabolism
often result in neurodegenerative conditions, with increasing evidence suggesting that …

Spinal muscular atrophy (SMA) type III and IV are autosomal recessive, slowly progressive
lower motor neuron syndromes. Nevertheless, wider cerebral involvement has been …

Degeneration and loss of lower motor neurons is the major pathological hallmark of spinal
muscular atrophy (SMA), resulting from low levels of ubiquitously-expressed survival motor …

Spinal muscular atrophy (SMA) is a progressive motor neuron disease caused by
deleterious variants in SMN1 that lead to a marked decrease in survival motor neuron (SMN) …