Myocardial tissue characterization and fibrosis by imaging

TD Karamitsos, A Arvanitaki, H Karvounis… - Cardiovascular …, 2020 - jacc.org
Myocardial fibrosis, either focal or diffuse, is a common feature of many cardiac diseases
and is associated with a poor prognosis for major adverse cardiovascular events. Although …

[HTML][HTML] Current understanding of the pathophysiology of myocardial fibrosis and its quantitative assessment in heart failure

T Liu, D Song, J Dong, P Zhu, J Liu, W Liu, X Ma… - Frontiers in …, 2017 - frontiersin.org
Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and
death. Myocardial fibrosis results from increased myofibroblast activity and excessive …

Myocardial fibrosis and cardiac decompensation in aortic stenosis

CWL Chin, RJ Everett, J Kwiecinski, AT Vesey… - JACC: Cardiovascular …, 2017 - jacc.org
Objectives: Cardiac magnetic resonance (CMR) was used to investigate the extracellular
compartment and myocardial fibrosis in patients with aortic stenosis, as well as their …

[HTML][HTML] Cardiac fibrosis in the pressure overloaded left and right ventricle as a therapeutic target

K Schimmel, K Ichimura, S Reddy, F Haddad… - Frontiers in …, 2022 - frontiersin.org
Myocardial fibrosis is a remodeling process of the extracellular matrix (ECM) following
cardiac stress.“Replacement fibrosis” describes the wound healing aspect in the acute …

Myocardial Interstitial Fibrosis in Nonischemic Heart Disease, Part 3/4: JACC Focus Seminar

J Díez, A González, JC Kovacic - Journal of the American College of …, 2020 - jacc.org
Myocardial interstitial fibrosis (MIF) is a histological hallmark of several cardiac diseases that
alter myocardial architecture and function and are associated with progression to heart …

Fibrosis imaging: current concepts and future directions

M Baues, A Dasgupta, J Ehling, J Prakash… - Advanced drug delivery …, 2017 - Elsevier
Fibrosis plays an important role in many different pathologies. It results from tissue injury,
chronic inflammation, autoimmune reactions and genetic alterations, and it is characterized …

[HTML][HTML] T1 mapping in cardiac MRI

D Radenkovic, S Weingärtner, L Ricketts, JC Moon… - Heart failure …, 2017 - Springer
Quantitative myocardial and blood T 1 have recently achieved clinical utility in numerous
pathologies, as they provide non-invasive tissue characterization with the potential to …

Noncontrast myocardial T1 mapping by cardiac magnetic resonance predicts outcome in patients with aortic stenosis

H Lee, JB Park, YE Yoon, EA Park, HK Kim… - JACC: Cardiovascular …, 2018 - jacc.org
Objectives: The aim of this study was to evaluate whether native T1 value of the myocardium
on cardiac magnetic resonance (CMR) could predict clinical events in patients with …

Myocardial fibrosis predicts ventricular tachyarrhythmias

M Disertori, M Masè, F Ravelli - Trends in cardiovascular medicine, 2017 - Elsevier
Myocardial fibrosis is a common pattern in the setting of different heart diseases, and
promotes ventricular tachyarrhythmias by creating a vulnerable substrate for reentrant …

Mechanisms of cardiac collagen deposition in experimental models and human disease

RT Cowling, D Kupsky, AM Kahn, LB Daniels… - Translational …, 2019 - Elsevier
The inappropriate deposition of extracellular matrix within the heart (termed cardiac fibrosis)
is associated with nearly all types of heart disease, including ischemic, hypertensive …