The efficacy of current standard chemotherapy is suboptimal due to the poor solubility and
short half-lives of chemotherapeutic agents, as well as their high toxicity and lack of …

Nanostructured lipid carriers (NLCs) are drug-delivery systems composed of both solid and
liquid lipids as a core matrix. It was shown that NLCs reveal some advantages for drug …

Opioid analgesics are commonly prescribed for acute and chronic pain, but are subject to
abuse. Consequently, toxicology testing programs are frequently implemented for both …

Buprenorphine is a promising drug for the treatment of chronic pain and opioid dependence.
The aim of the present work was to evaluate the feasibility of lipid nanoparticles with different …

Background Quantitative urine buprenorphine testing is used to monitor patients receiving
buprenorphine for the treatment of opioid use disorder (OUD), however the interpretation of …

Chronic intrauterine exposure to psychoactive drugs often results in neonatal opioid
withdrawal syndrome (NOWS). When nonpharmacologic measures are insufficient in …

The goal of this review is to provide a recent examination of the pharmacodynamics as well
as pharmacokinetics, misuse potential, toxicology, and prenatal consequences of …

Buprenorphine (BUP) is a commonly prescribed medication for the treatment of opioid use
disorder (OUD). As prescriptions increase in North Carolina, BUP is more frequently …

In addition to analgesia opioids may also enhance pain sensitivity. Opioid-induced
hyperalgesia, typically associated with potent mu-opioid agonists (eg fentanyl, morphine …

The abuse of buprenorphine and methadone has grown into a rising worldwide issue. After
their consumption, buprenorphine, methadone and their metabolites can be found in the …