The disposition of morphine and its 3-and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of …

RW Milne, RL Nation, AA Somogyi - Drug metabolism reviews, 1996 - Taylor & Francis
The purposes of this comprehensive review are: first. to introduce the reader to the historical
and current uses for morphine and to give a brief outline of the relevant physicochemical …

Morphine-6-glucuronide: an analgesic of the future?

J Lötsch, G Geisslinger - Clinical pharmacokinetics, 2001 - Springer
Abstract Morphine-6-β-glucuronide (M6G) is an opioid agonist that plays a role in the clinical
effects of morphine. Although M6G probably crosses the blood-brain barrier with difficulty …

[图书][B] Karch's pathology of drug abuse

SB Karch, O Drummer - 2008 - taylorfrancis.com
Written for practitioners in the field, this critically acclaimed bestseller provides authoritative
information focused on the investigation of drug-related deaths and practical approaches to …

Morphine pharmacokinetics and metabolism in humans: enterohepatic cycling and relative contribution of metabolites to active opioid concentrations

J Hasselström, J Säwe - Clinical pharmacokinetics, 1993 - Springer
Summary Morphine, morphine-6-glucuronide (M6G), morphine-3-glucuronide (M3G) and
normorphine were analysed with high performance liquid chromatography in plasma and …

Xenobiotic metabolizing enzymes of the kidney

EA Lock, CJ Reed - Toxicologic pathology, 1998 - journals.sagepub.com
The kidney possesses most of the common xenobiotic metabolizing enzymes, and is thus
able to make an important contribution to the body's metabolism of drugs and foreign …

General anesthetic techniques in ruminants

GL Carroll, SM Hartsfield - Veterinary Clinics of North America: Food Animal …, 1996 - Elsevier
This article reviews the injectable and inhalant techniques used for general anesthesia in
cattle, sheep, and goats. Particular attention is given to recently developed injectable and …

[PDF][PDF] Recent advances and developments in the clinical use of iv opioids during the peroperative period.

JW Sear - British journal of anaesthesia, 1998 - researchgate.net
The provision of general anaesthesia requires the administration of drugs to suppress
movement in response to noxious stimuli and responses to autonomic stimulation of the …

Open loop control of multiple drug effects in anesthesia

DR Wada, DS Ward - IEEE transactions on biomedical …, 1995 - ieeexplore.ieee.org
Current open-loop computer-controlled infusion pumps do not explicitly control the transient
adverse side effects of intravenous drugs during anesthesia. The authors used optimal …

Pharmacokinetic profiles of three dose rates of morphine sulfate following single intravenous, intramuscular, and subcutaneous administration in the goat

E Gordon, L Dirikolu, CC Liu, AV Ulanov… - Journal of veterinary …, 2022 - Wiley Online Library
This study aimed to evaluate pharmacokinetic profiles of morphine in goats following a
single dose administered intravenously, intramuscularly, or subcutaneously at 0.1 mg/kg …

Influence of renal failure on the disposition of morphine, morphine-3-glucuronide and morphine-6-glucuronide in sheep during intravenous infusion with morphine

RW Milne, CF McLean, LE Mather, RL Nation… - … of Pharmacology and …, 1997 - ASPET
The influence of experimentally induced renal failure on the disposition of morphine,
morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) was examined in seven …