Prevention of LPS‐induced acute lung injury in mice by progranulin

Z Guo, Q Li, Y Han, Y Liang, Z Xu… - Mediators of …, 2012 - Wiley Online Library
The acute respiratory distress syndrome (ARDS), a clinical complication of severe acute
lung injury (ALI) in humans, is a leading cause of morbidity and mortality in critically ill …

Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia

Y Yuan, I Alwis, MCL Wu, Z Kaplan… - Science Translational …, 2017 - science.org
Gut ischemia is common in critically ill patients, promoting thrombosis and inflammation in
distant organs. The mechanisms linking hemodynamic changes in the gut to remote organ …

Heat shock protein 90 inhibitors prevent LPS-induced endothelial barrier dysfunction by disrupting RhoA signaling

AD Joshi, C Dimitropoulou, G Thangjam… - American journal of …, 2014 - atsjournals.org
Permeability of the endothelial monolayer is increased when exposed to the bacterial
endotoxin LPS. Our previous studies have shown that heat shock protein (Hsp) 90 inhibitors …

MicroRNAs are dynamically regulated and play an important role in LPS-induced lung injury

ZG Cai, SM Zhang, Y Zhang, YY Zhou… - Canadian journal of …, 2012 - cdnsciencepub.com
Acute lung injury is characterized by an increase of inflammatory reaction and severe lung
edema. Even if there have been great advances in the identification of genes and signaling …

Blockade of interleukin‐17 restrains the development of acute lung injury

Q Li, Y Gu, Q Tu, K Wang, X Gu… - Scandinavian Journal of …, 2016 - Wiley Online Library
The acute respiratory distress syndrome (ARDS), a clinical complication of severe acute
lung injury (ALI) in humans, is a leading cause of morbidity and mortality in critically ill …

Marilines A–C: Novel Phthalimidines from the Sponge‐Derived Fungus Stachylidium sp.

C Almeida, Y Hemberger, SM Schmitt… - … A European Journal, 2012 - Wiley Online Library
A marine‐derived fungus of the genus Stachylidium was isolated from the sponge
Callyspongia cf. C. flammea. Chemical investigation of the bioactive fungal extract led to the …

[HTML][HTML] MicroRNA-92a antagonism attenuates lipopolysaccharide (LPS)-induced pulmonary inflammation and injury in mice through suppressing the PTEN/AKT/NF …

L Fu, P Zhu, S Qi, C Li, K Zhao - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Overwhelming lung inflammation is a key feature of acute lung injury (ALI). MicroRNAs
(miRNAs) have been implicated in the regulation diverse cellular processes including the …

Enforced expression of miR-125b attenuates LPS-induced acute lung injury

Z Guo, Y Gu, C Wang, J Zhang, S Shan, X Gu, K Wang… - Immunology letters, 2014 - Elsevier
The acute respiratory distress syndrome (ARDS), a severe form of acute lung injury (ALI) in
humans, is a leading cause of morbidity and mortality in critically ill patients. Despite …

Acute Lung Injury Is Reduced in fat-1 Mice Endogenously Synthesizing n-3 Fatty Acids

K Mayer, A Kiessling, J Ott, MB Schaefer… - American journal of …, 2009 - atsjournals.org
Rationale: Acute lung injury (ALI) remains an important cause of mortality in intensive care
units. Inflammation is controlled by cytokines and eicosanoids derived from the n-6 fatty acid …

Peroxisome proliferator-activated receptor-α reduces inflammation and vascular leakage in a murine model of acute lung injury

MB Schaefer, A Pose, J Ott, M Hecker… - European …, 2008 - Eur Respiratory Soc
Acute lung injury (ALI) still represents a major cause of morbidity and mortality in intensive
care units. Beneficial effects have been described after activation of the peroxisome …