Sensitivity analysis of in silico fluid simulations to predict thrombus formation after left atrial appendage occlusion

J Mill, V Agudelo, AL Olivares, MI Pons, E Silva… - Mathematics, 2021 - mdpi.com
Atrial fibrillation (AF) is nowadays the most common human arrhythmia and it is considered
a marker of an increased risk of embolic stroke. It is known that 99% of AF-related thrombi …

[HTML][HTML] Pulmonary vein flow split effects in patient-specific simulations of left atrial flow

E Durán, M García-Villalba, P Martínez-Legazpi… - Computers in biology …, 2023 - Elsevier
Disruptions to left atrial (LA) blood flow, such as those caused by atrial fibrillation (AF), can
lead to thrombosis in the left atrial appendage (LAA) and an increased risk of systemic …

Joint analysis of morphological parameters and in silico haemodynamics of the left atrial appendage for thrombogenic risk assessment

MI Pons, J Mill, A Fernandez-Quilez… - Journal of …, 2022 - Wiley Online Library
Background. Atrial fibrillation (AF) is considered the most common human arrhythmia. In
nonvalvular AF, around 99% of thrombi are formed in the left atrial appendage (LAA) …

The role of the pulmonary veins on left atrial flow patterns and thrombus formation

J Mill, J Harrison, M Saiz-Vivo, C Albors, X Morales… - Scientific Reports, 2024 - nature.com
Atrial fibrillation (AF) is the most common human arrhythmia, forming thrombi mostly in the
left atrial appendage (LAA). However, the relation between LAA morphology, blood patterns …

Personalized biomechanical insights in atrial fibrillation: opportunities & challenges

Å Telle, C Bargellini, Y Chahine… - Expert Review of …, 2023 - Taylor & Francis
Introduction Atrial fibrillation (AF) is an increasingly prevalent and significant worldwide
health problem. Manifested as an irregular atrial electrophysiological activation, it is …

Elevated atrial blood stasis in paroxysmal atrial fibrillation during sinus rhythm: a patient-specific computational fluid dynamics study

S Bäck, I Skoda, J Lantz, L Henriksson… - Frontiers in …, 2023 - frontiersin.org
Introduction Atrial fibrillation (AF) is associated with an increased risk of stroke, often caused
by thrombi that form in the left atrium (LA), and especially in the left atrial appendage (LAA) …

Slow blood-flow in the left atrial appendage is associated with stroke in atrial fibrillation patients

N Paliwal, HC Park, Y Mao, SJ Hong, Y Lee… - Heliyon, 2024 - cell.com
Background Atrial fibrillation (AF) patients are at high risk of stroke with∼ 90% clots
originating from the left atrial appendage (LAA). Clinical understanding of blood-flow based …

Left atrial thrombus—are all atria and appendages equal?

A Cresti, O Camara - Cardiac Electrophysiology Clinics, 2023 - cardiacep.theclinics.com
Modern science shows how much humans are alike, with 99.9% of genome of any 2
individuals being identical. The homogeneity in human organ's structure and function is not …

Impact of left atrial wall motion assumptions in fluid simulations on proposed predictors of thrombus formation

HA Kjeldsberg, C Albors, J Mill… - International Journal …, 2024 - Wiley Online Library
Atrial fibrillation (AF) poses a significant risk of stroke due to thrombus formation, which
primarily occurs in the left atrial appendage (LAA). Medical image‐based computational fluid …

On the importance of fundamental computational fluid dynamics toward a robust and reliable model of left atrial flows

E Khalili, C Daversin‐Catty, AL Olivares… - International Journal …, 2024 - Wiley Online Library
Computational fluid dynamics (CFD) studies of left atrial flows have reached a sophisticated
level, for example, revealing plausible relationships between hemodynamics and stresses …