Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …

Iron has been increasingly implicated in the pathology of neurodegenerative diseases. In
the past decade, development of the new magnetic resonance imaging technique …

Objective To elucidate the relationship between disease stage in amyotrophic lateral
sclerosis (ALS), as measured with the King's Clinical Staging System, and cognitive and …

The early motor manifestations of sporadic amyotrophic lateral sclerosis (ALS), while rarely
documented, reflect failure of adaptive complex motor skills. The development of these skills …

Pain is a largely neglected symptom in patients with amyotrophic lateral sclerosis (ALS)
although it is reported by most of these patients. It occurs at all stages of the disease and can …

Objective Damage to the cerebral tissue structural connectivity associated with amyotrophic
lateral sclerosis (ALS), which extends beyond the motor pathways, can be visualised by …

Background and purpose Recommendations for using fluorodeoxyglucose positron
emission tomography (FDG‐PET) to support the diagnosis of dementing neurodegenerative …

The human motor cortex comprises a microcircuit of five interconnected layers with different
cell types. In this Review, we use a layer-specific and cell-specific approach to integrate …

Introduction The use of machine learning (ML) techniques in healthcare encompasses an
emerging concept that envisages vast contributions to the tackling of rare diseases. In this …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two progressive,
fatal neurodegenerative syndromes with considerable clinical, genetic and pathological …