• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

In the absence of contemporary, population-based epidemiological studies, estimates of the
incidence and prevalence of the inherited cardiomyopathies have been derived from …

Hypertrophic cardiomyopathy (HCM) is a common, serious, genetic heart disorder. Rare
pathogenic variants in sarcomere genes cause HCM, but with unexplained phenotypic …

Background: The term “end stage” has been used to describe hypertrophic cardiomyopathy
(HCM) with left ventricular systolic dysfunction (LVSD), defined as occurring when left …

Hypertrophic cardiomyopathy (HCM) was traditionally described as an autosomal dominant
Mendelian disease but is now increasingly recognized as having a complex genetic …

Aims The aim of this study was to determine the frequency of heterozygous truncating
ALPK3 variants (ALPK3 tv) in patients with hypertrophic cardiomyopathy (HCM) and confirm …

Hypertrophic cardiomyopathy (HCM) is an umbrella term for a heterogeneous heart muscle
disease that was historically (and still is) defined by the detection of left ventricular (LV) …

Hypertrophic cardiomyopathy is the most common genetic heart disease. Biomarkers,
molecules measurable in the blood, could inform the clinician by aiding in diagnosis …

Background Myocardial replacement fibrosis is one of the major histologic features of
hypertrophic cardiomyopathy (HCM), but its characteristics have not been well delineated …

Background: Over the last 50 years, the epidemiology of hypertrophic cardiomyopathy
(HCM) has changed because of increased awareness and availability of advanced …