Amyotrophic lateral sclerosis (ALS) encompasses a heterogeneous group of phenotypes
with different progression rates, varying degree of extra-motor involvement and divergent …

Background Amyotrophic lateral sclerosis (ALS) is increasingly recognised as a multi-
system disorder, presenting with common and impactful non-motor symptoms, such as …

Objective Cerebellar disease burden and cerebro-cerebellar connectivity alterations are
poorly characterised in amyotrophic lateral sclerosis (ALS) despite the likely contribution of …

The description of group-level, genotype-and phenotype-associated imaging traits is
academically important, but the practical demands of clinical neurology centre on the …

Background and purpose Considerable functional reorganization takes place in
amyotrophic lateral sclerosis (ALS) in face of relentless structural degeneration. This study …

Although hippocampal involvement in amyotrophic lateral sclerosis (ALS) has been
consistently highlighted by postmortem studies, memory impairment remains under …

Temporal lobe studies in motor neuron disease overwhelmingly focus on white matter
alterations and cortical grey matter atrophy. Reports on amygdala involvement are …

The thalamus is a key cerebral hub relaying a multitude of corticoefferent and corticoafferent
connections and mediating distinct extrapyramidal, sensory, cognitive and behavioural …

Amyotrophic lateral sclerosis (ALS) is the most common adult onset motor neuron disease
with no effective disease modifying therapies at present. Spinal cord degeneration is a …

Amyotrophic lateral sclerosis (ALS) is associated with considerable clinical heterogeneity
spanning from diverse disability profiles, differences in UMN/LMN involvement, divergent …