Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Generative pretrained models have achieved remarkable success in various domains such
as language and computer vision. Specifically, the combination of large-scale diverse …

Apoptosis is a form of cell death by which the body maintains the homeostasis of the internal
environment. Apoptosis is an initiative cell death process that is controlled by genes and is …

The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic
fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non …

The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that
plays a vital role in the unfolded protein response (UPR). Under endoplasmic reticulum (ER) …

Cancer is the second biggest cause of death worldwide. Despite a number of studies being
conducted, the effective mechanism for treating cancer has not yet been fully understood …

The endoplasmic reticulum is an organelle with multiple functions. The synthesis of
transmembrane proteins and proteins that are to be secreted occurs in this organelle. Many …

Protein-folding stress at the endoplasmic reticulum (ER) is a salient feature of specialized
secretory cells and is also involved in the pathogenesis of many human diseases. ER stress …

Radiotherapy is one of the major cancer treatment strategies. Exposure to penetrating
radiation causes cellular stress, directly or indirectly, due to the generation of reactive …