Alzheimer disease (AD) is the most common contributor to dementia in the world, but
strategies that slow or prevent its clinical progression have largely remained elusive, until …

The cerebrospinal fluid (CSF) is a complex solution that circulates around the CNS, and
whose composition changes as a function of an animal's physiological state. Ciliated …

Brain infiltration of peripheral immune cells and their interactions with brain-resident cells
may contribute to Alzheimer's disease (AD) pathology. To examine these interactions, in the …

Neurodegenerative diseases, including Alzheimer's disease (AD), are characterized by
innate immune-mediated inflammation, but functional and mechanistic effects of the …

Primary Sjögren's syndrome (pSS) is a systemic autoimmune inflammatory disease mainly
defined by T cell–dominated destruction of exocrine glands. Currently, CD8+ T cells are …

Middle age has historically been an understudied period of life compared to older age, when
cognitive and brain health decline are most pronounced, but the scope for intervention may …

In recent decades there has been a large focus on understanding the mechanisms of
peripheral immune cell infiltration into the central nervous system (CNS) in …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Background Neuroinflammation is involved in the pathophysiology of Alzheimer's disease
(AD), including immune-linked genetic variants and molecular pathways, microglia and …

Efficient protein turnover is essential for cellular homeostasis and organ function. Loss of
proteostasis is a hallmark of aging culminating in severe dysfunction of protein turnover. To …