A mathematical model that integrates cardiac electrophysiology, mechanics, and fluid dynamics: Application to the human left heart

M Bucelli, A Zingaro, PC Africa… - … journal for numerical …, 2023 - Wiley Online Library
We propose a mathematical and numerical model for the simulation of the heart function that
couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and …

Beyond CFD: Emerging methodologies for predictive simulation in cardiovascular health and disease

EL Schwarz, L Pegolotti, MR Pfaller… - Biophysics Reviews, 2023 - pubs.aip.org
Physics-based computational models of the cardiovascular system are increasingly used to
simulate hemodynamics, tissue mechanics, and physiology in evolving healthy and …

lifex-cfd: An open-source computational fluid dynamics solver for cardiovascular applications

PC Africa, I Fumagalli, M Bucelli, A Zingaro… - Computer Physics …, 2024 - Elsevier
Computational fluid dynamics (CFD) is an important tool for the simulation of the
cardiovascular function and dysfunction. Due to the complexity of the anatomy, the …

Impact of atrial fibrillation on left atrium haemodynamics: A computational fluid dynamics study

M Corti, A Zingaro, AM Quarteroni - Computers in Biology and Medicine, 2022 - Elsevier
We analyse the haemodynamics of the left atrium, highlighting differences between healthy
individuals and patients affected by atrial fibrillation. The computational study is based on …

A geometric multiscale model for the numerical simulation of blood flow in the human left heart

A Zingaro, I Fumagalli, L Dede, M Fedele… - arXiv preprint arXiv …, 2021 - arxiv.org
We present a new computational model for the numerical simulation of blood flow in the
human left heart. To this aim, we use the Navier-Stokes equations in an Arbitrary Lagrangian …

[HTML][HTML] An electromechanics-driven fluid dynamics model for the simulation of the whole human heart

A Zingaro, M Bucelli, R Piersanti, F Regazzoni… - Journal of …, 2024 - Elsevier
We introduce a multiphysics and geometric multiscale computational model, suitable to
describe the hemodynamics of the whole human heart, driven by a four-chamber …

[HTML][HTML] Pulmonary vein flow split effects in patient-specific simulations of left atrial flow

E Durán, M García-Villalba, P Martínez-Legazpi… - Computers in biology …, 2023 - Elsevier
Disruptions to left atrial (LA) blood flow, such as those caused by atrial fibrillation (AF), can
lead to thrombosis in the left atrial appendage (LAA) and an increased risk of systemic …

A comprehensive mathematical model for cardiac perfusion

A Zingaro, C Vergara, L Dede', F Regazzoni… - Scientific Reports, 2023 - nature.com
The aim of this paper is to introduce a new mathematical model that simulates myocardial
blood perfusion that accounts for multiscale and multiphysics features. Our model …

Global sensitivity analysis of four chamber heart hemodynamics using surrogate models

E Karabelas, S Longobardi… - IEEE Transactions …, 2022 - ieeexplore.ieee.org
Computational Fluid Dynamics (CFD) is used to assist in designing artificial valves and
planning procedures, focusing on local flow features. However, assessing the impact on …

[HTML][HTML] The role of computational methods in cardiovascular medicine: a narrative review

I Fumagalli, S Pagani, C Vergara, DA Adebo… - Translational …, 2024 - ncbi.nlm.nih.gov
Methods We developed computational models of the physical processes encompassed by
the heart function (electrophysiology, electrical activation, force generation, mechanics …