Motor neuron diseases (MNDs) like amyotrophic lateral sclerosis (ALS) are progressive
neurodegenerative disorders affecting upper and lower motor neurons (UMN and LMN) …

Disease heterogeneity in amyotrophic lateral sclerosis poses a substantial challenge in drug
development. Categorization based on clinical features alone can help us predict the …

Background: Motor neuron diseases (MNDs) are progressive neurodegenerative disorders
characterized by motor impairment and non-motor symptoms. The involvement of the …

Motor neuron diseases (MNDs), such as amyotrophic lateral sclerosis (ALS), are a group of
devastating and progressive neurodegenerative disorders that affect the upper and lower …

Objective Magnetic resonance imaging can detect neurodegenerative iron accumulation in
the motor cortex, called the motor band sign. This study aims to evaluate its …

Amyotrophic lateral sclerosis (ALS) currently lacks the useful diagnostic biomarkers. The
current diagnosis of ALS is mainly depended on the clinical manifestations, which …

Background and objectives Animal models for motor neuron diseases (MND) such as
amyotrophic lateral sclerosis (ALS) are commonly used in preclinical research. However, it …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by motor neuron degeneration. The development of ALS involves metabolite …

Identifying upper motor neuron (UMN) dysfunction is fundamental to the diagnosis and
understanding of disease pathogenesis in motor neuron disease (MND). The clinical …

Amyotrophic lateral sclerosis (ALS) affects the cerebral cortex layer-dependently, most
notably by the foremost targeting of upper motor neurons (UMNs) sited in layer Vb. Previous …