Composite pain biomarker signatures for objective assessment and effective treatment
Pain is a subjective sensory experience that can, mostly, be reported but cannot be directly
measured or quantified. Nevertheless, a suite of biomarkers related to mechanisms, neural …
measured or quantified. Nevertheless, a suite of biomarkers related to mechanisms, neural …
The cerebral signature for pain perception and its modulation
Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …
knowledge of how pain signals are initially interpreted and subsequently transmitted and …
An fMRI-based neurologic signature of physical pain
Background Persistent pain is measured by means of self-report, the sole reliance on which
hampers diagnosis and treatment. Functional magnetic resonance imaging (fMRI) holds …
hampers diagnosis and treatment. Functional magnetic resonance imaging (fMRI) holds …
Pediatric chronic pain: biopsychosocial assessment and formulation
C Liossi, RF Howard - Pediatrics, 2016 - publications.aap.org
Dr Liossi conducted the initial literature review, and drafted and revised the initial
manuscript; Dr Howard further contributed to the literature review and reviewed and revised …
manuscript; Dr Howard further contributed to the literature review and reviewed and revised …
From nociception to pain perception: imaging the spinal and supraspinal pathways
Functional imaging techniques have allowed researchers to look within the brain, and
revealed the cortical representation of pain. Initial experiments, performed in the early …
revealed the cortical representation of pain. Initial experiments, performed in the early …
The analgesic effects of opioids and immersive virtual reality distraction: evidence from subjective and functional brain imaging assessments
HG Hoffman, TL Richards, T Van Oostrom… - Anesthesia & …, 2007 - journals.lww.com
BACKGROUND: Immersive virtual reality (VR) is a novel form of distraction analgesia, yet its
effects on pain-related brain activity when used adjunctively with opioid analgesics are …
effects on pain-related brain activity when used adjunctively with opioid analgesics are …
[HTML][HTML] The potential role of sensory testing, skin biopsy, and functional brain imaging as biomarkers in chronic pain clinical trials: IMMPACT considerations
SM Smith, RH Dworkin, DC Turk, R Baron… - The Journal of …, 2017 - Elsevier
Valid and reliable biomarkers can play an important role in clinical trials as indicators of
biological or pathogenic processes or as a signal of treatment response. Currently, there are …
biological or pathogenic processes or as a signal of treatment response. Currently, there are …
Treating pain with pain: supraspinal mechanisms of endogenous analgesia elicited by heterotopic noxious conditioning stimulation
While being exposed to an intensive tonic pain stimulus at one area of the body, another
phasic pain stimulus applied to a remote site is perceived as less painful. The …
phasic pain stimulus applied to a remote site is perceived as less painful. The …
Dissociable influences of opiates and expectations on pain
LY Atlas, RA Whittington, MA Lindquist… - Journal of …, 2012 - Soc Neuroscience
Placebo treatments and opiate drugs are thought to have common effects on the opioid
system and pain-related brain processes. This has created excitement about the potential for …
system and pain-related brain processes. This has created excitement about the potential for …
Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain
S Imai, D Ikegami, A Yamashita, T Shimizu, M Narita… - Brain, 2013 - academic.oup.com
A multiplex analysis for profiling the expression of candidate genes along with epigenetic
modification may lead to a better understanding of the complex machinery of neuropathic …
modification may lead to a better understanding of the complex machinery of neuropathic …