Administration of anesthetic agents fundamentally shifts the responsibility for maintenance of
homeostasis from the patient and their intrinsic physiological regulatory mechanisms to the …

Remifentanil (Ultiva™), a fentanyl derivative, is an ultra-short acting, nonspecific esterase-
metabolised, selective μ-opioid receptor agonist, with a pharmacodynamic profile typical of …

Wepresent a method for investigating the dynamic pharmacological modulation of pain-
related brain activity, measured by BOLD-contrast fMRI. Noxious thermal stimulation was …

Summary Abstract Remifentanil (Ultiva™), a 4-anilidopiperidine derivative of fentanyl, is an
ultra-short-acting μ-opioid receptor agonist indicated to provide analgesia and sedation in …

To understand and exploit centrally acting drugs requires reliable measures of their time
course of action in the human brain. Functional magnetic resonance imaging (fMRI) is able …

Major goals in neurosurgical anesthesia are to provide adequate tissue perfusion to the
brain (and spinal cord) so that the regional metabolic demand is met and to provide …

Opioid binding to the cerebral blood vessels may affect vascular responsiveness and hence
confound interpretation of blood oxygen level-dependent (BOLD) responses, which are …

Background The aim of this study was to investigate the independent effect of remifentanil
on the approximate entropy (ApEn) in frontoparietal montages. The authors investigated …

The blood-oxygenation-level-dependent (BOLD) signal is an indirect hemodynamic signal
that is sensitive to cerebral blood flow (CBF), cerebral blood volume (CBV) and cerebral …

IMPLICATIONS: Remifentanil bolus in severe head trauma patients in the intensive care unit
induces an increase in intracranial pressure related to a decrease in mean arterial blood …