Gain-of-function mutations in the Cu, Zn-superoxide dismutase (SOD1) gene are implicated
in progressive motor neuron death and paralysis in one form of inherited amyotrophic lateral …

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder, in which the
clinical manifestations may be influenced by genetic and unknown environmental factors …

Down syndrome (DS) is characterized by brain hypotrophy and intellectual disability starting
from early life stages. Accumulating evidence shows that the phenotypic features of the DS …

Background Brainstem pathology is a hallmark feature of ALS, yet most imaging studies
focus on cortical grey matter alterations and internal capsule white matter pathology …

Magnetic resonance imaging (MRI) is a well-established tool in clinical practice and
research on human neurological disorders. Translational MRI research utilizing rodent …

NAP (davunetide) is a novel neuroprotective compound with mechanism of action that
appears to involve microtubule (MT) stabilization and repair. To evaluate, for the first time …

Amyotrophic lateral sclerosis (ALS) is a progressive, fatal, neurodegenerative disorder
caused by the degeneration of motor neurons in the CNS, which results in complete …

Down syndrome (DS) is a genetic pathology caused by the triplication of human
chromosome 21. Although individuals with DS have various medical problems, intellectual …

Down syndrome (DS), affecting 1/700 live births, is the major genetic cause of mental
retardation (MR), a cognitive disorder with hard impact on public health. DS brain is …

Down syndrome (DS), the most frequent genetic disorder leading to mental retardation (MR),
is caused by three copies of human chromosome 21 (HC21). Trisomic and transgenic …