Clear guidelines on the proper care and use of laboratory animals are being sought by
researchers and members of the many committees formed to oversee animal care at …

The pulmonary kinetics of fentanyl and alfentanil were studied quantitatively in two groups of
five and six surgical patients, respectively, after the induction of anaesthesia. A mixture of …

The purpose of the analysis was to evaluate if 10 mg naloxone, administered
intramuscularly, could reverse or prevent opioid‐induced respiratory depression (OIRD) …

These studies were conducted to determine the effect of anesthetic drugs on tissue
perfusion and O2 supply in the brain with focal cerebral edema. Using an open cranium …

The objective of this study was to analyze the effects of various anesthetics on the formation
of brain edema resulting from a focal cryogenic lesion. Thirty rabbits (six per group) were …

We describe a method of rapidly obtaining a specified steady state plasma concentration of
an intravenous drug within precise limits. The technique requires an initial bolus to raise the …

Although the limitations of administering fentanyl in bolus doses were appreciated some
years ago, it was not until 1979 that the practical advantages offentanyl infusion were first …