Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

YQ He, CC Zhou, LY Yu, L Wang, J Deng… - Pharmacological …, 2021 - Elsevier
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome
(ARDS) as common life-threatening lung diseases with high mortality rates are mostly …

[HTML][HTML] On facing the SARS-CoV-2 (COVID-19) with combination of nanomaterials and medicine: possible strategies and first challenges

VS Sivasankarapillai, AM Pillai, A Rahdar, AP Sobha… - Nanomaterials, 2020 - mdpi.com
Global health is facing the most dangerous situation regarding the novel severe acute
respiratory syndrome called coronavirus 2 (SARS-CoV-2), which is widely known as the …

Alternative and natural therapies for acute lung injury and acute respiratory distress syndrome

VJ Patel, S Biswas Roy, HJ Mehta… - BioMed research …, 2018 - Wiley Online Library
Introduction. Acute respiratory distress syndrome (ARDS) is a complex clinical syndrome
characterized by acute inflammation, microvascular damage, and increased pulmonary …

[HTML][HTML] Artesunate: A review of its therapeutic insights in respiratory diseases

J Zhang, Y Li, J Wan, M Zhang, C Li, J Lin - Phytomedicine, 2022 - Elsevier
Background Artesunate, as a semi-synthetic artemisinin derivative of sesquiterpene lactone,
is widely used in clinical antimalarial treatment due to its endoperoxide group. Recent …

Chlorogenic acid reduces inflammation by inhibiting the elevated expression of KAT2A to ameliorate lipopolysaccharide‐induced acute lung injury

B Lv, J Guo, Y Du, Y Chen, X Zhao, B Yu… - British Journal of …, 2023 - Wiley Online Library
Background and Purpose Respiratory diseases have become a global health problem and
may lead to acute lung injury (ALI) in severe cases. ALI progression is associated with …

Ruscogenin attenuates sepsis-induced acute lung injury and pulmonary endothelial barrier dysfunction via TLR4/Src/p120-catenin/VE-cadherin signalling pathway

Y Wang, L Xue, Y Wu, J Zhang, Y Dai… - Journal of Pharmacy …, 2021 - academic.oup.com
Objectives Sepsis-associated acute lung injury (ALI) occurs with the highest morbidity and
carries the highest mortality rates among the pathogenies of ALI. Ruscogenin (RUS) has …

[HTML][HTML] Mesenchymal stromal cells ameliorate acute lung injury induced by LPS mainly through stanniocalcin-2 mediating macrophage polarization

H Lv, Q Liu, Y Sun, X Yi, X Wei, W Liu… - Annals of …, 2020 - ncbi.nlm.nih.gov
Background Acute lung injury (ALI) is a devastating syndrome with no effective
pharmacological therapies in the clinic. Mesenchymal stromal cells (MSCs) have been …

Artesunate inhibits renal ischemia-reperfusion-mediated remote lung inflammation through attenuating ROS-induced activation of NLRP3 inflammasome

Z Liu, M Qu, L Yu, P Song, Y Chang - Inflammation, 2018 - Springer
The molecular mechanisms of acute lung injury (ALI) are closely associated with nucleotide-
binding domains and leucine-rich repeat (NLR) pyrin domains containing 3 (NLRP3) …

Targeted Delivery of the Pan‐Inflammasome Inhibitor MM01 as an Alternative Approach to Acute Lung Injury Therapy

A García‐Fernández, M Sancho… - Advanced …, 2023 - Wiley Online Library
Acute lung injury (ALI) is a severe pulmonary disorder responsible for high percentage of
mortality and morbidity in intensive care unit patients. Current treatments are ineffective, so …

Design and synthesis novel di-carbonyl analogs of curcumin (DACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI)

J Qian, X Chen, S Shu, W Zhang, B Fang… - European Journal of …, 2019 - Elsevier
A novel series of di-carbonyl analogs of curcumin (DACs) were prepared and evaluated for
their anti-inflammatory properties. Preliminary results showed that a vast majority of …