Rationale for a multi-factorial approach for the reversal of cognitive decline in Alzheimer's disease and MCI: a review

RV Rao, KG Subramaniam, J Gregory… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative disease
typically characterized by memory loss, personality changes, and a decline in overall …

Unique trans-kingdom microbiome structural and functional signatures predict cognitive decline in older adults

DS Chaudhari, S Jain, VK Yata, SP Mishra, A Kumar… - Geroscience, 2023 - Springer
The prevalence of age-related cognitive disorders/dementia is increasing, and effective
prevention and treatment interventions are lacking due to an incomplete understanding of …

[HTML][HTML] Dense data enables 21st century clinical trials

JC Roach, JF Hodes, CC Funk… - … Research & Clinical …, 2022 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is one of the most significant challenges of our time. We need a
diverse research portfolio. We cannot afford to shut down avenues of research. A century of …

A Remotely Coached Multimodal Lifestyle Intervention for Alzheimer's Disease Ameliorates Functional and Cognitive Outcomes

JC Roach, MK Rapozo, J Hara… - Journal of …, 2023 - content.iospress.com
Background: Comprehensive treatment of Alzheimer's disease and related dementias
(ADRD) requires not only pharmacologic treatment but also management of existing medical …

A multimodal intervention for Alzheimer's disease results in multifaceted systemic effects reflected in blood and ameliorates functional and cognitive outcomes

JC Roach, L Edens, DR Markewych, MK Rapozo… - medRxiv, 2022 - medrxiv.org
Abstract Introduction Comprehensive treatment of Alzheimer's disease and related
dementias (ADRD) requires not only pharmacologic treatment but also management of …

LETHE: A Digital Intervention for Cognitive Decline

VS Loukas, T Kassiotis, IL Martinez… - 2023 45th Annual …, 2023 - ieeexplore.ieee.org
Dementia is the main cause of disability in elderly populations. It has been shown that the
risk factors of dementia are a mixture of pathological, lifestyle and heritable factors, with …