Pulmonary surfactant: a mighty thin film

F Possmayer, YY Zuo, RAW Veldhuizen… - Chemical …, 2023 - ACS Publications
Pulmonary surfactant is a critical component of lung function in healthy individuals. It
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing …

A roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases

S He, J Gui, K Xiong, M Chen, H Gao, Y Fu - Journal of nanobiotechnology, 2022 - Springer
Pulmonary drug delivery is a highly attractive topic for the treatment of infectious lung
diseases. Drug delivery via the pulmonary route offers unique advantages of no first-pass …

Pulmonary surfactant–biomimetic nanoparticles potentiate heterosubtypic influenza immunity

J Wang, P Li, Y Yu, Y Fu, H Jiang, M Lu, Z Sun, S Jiang… - Science, 2020 - science.org
INTRODUCTION Current influenza vaccines must be refreshed annually to address constant
mutations of viral hemagglutinin (HA) and neuraminidase (NA) genes because the vaccines …

Evolution of surfactant therapy for respiratory distress syndrome: past, present, and future

S Sardesai, M Biniwale, F Wertheimer, A Garingo… - Pediatric …, 2017 - nature.com
Respiratory distress syndrome (RDS) due to surfactant deficiency is the most common cause
of respiratory failure in preterm infants. Tremendous progress has been made since the …

Proteomic and lipidomic analysis of nanoparticle corona upon contact with lung surfactant reveals differences in protein, but not lipid composition

SS Raesch, S Tenzer, W Storck, A Rurainski, D Selzer… - ACS …, 2015 - ACS Publications
Pulmonary surfactant (PS) constitutes the first line of host defense in the deep lung. Because
of its high content of phospholipids and surfactant specific proteins, the interaction of inhaled …

Inhalable nanovaccine with biomimetic coronavirus structure to trigger mucosal immunity of respiratory tract against COVID-19

B Zheng, W Peng, M Guo, M Huang, Y Gu… - Chemical Engineering …, 2021 - Elsevier
The COVID-19 pandemic caused by SARS-CoV-2 seriously threatens global public health. It
has previously been confirmed that SARS-CoV-2 is mainly transmitted between people …

The Lord of the Lungs: The essential role of pulmonary surfactant upon inhalation of nanoparticles

C Garcia-Mouton, A Hidalgo, A Cruz… - European Journal of …, 2019 - Elsevier
The rapid development of nanotechnology is opening a huge world of promising
possibilities in healthcare, but this is also increasing the necessity to study the potential risk …

Understanding the principle biophysics concepts of pulmonary surfactant in health and disease

C Autilio, J Pérez-Gil - Archives of Disease in Childhood-Fetal and …, 2019 - fn.bmj.com
Pulmonary surfactant (PS) is a lipid-protein complex essential to stabilise the delicate
structure of mammalian alveoli along with successive compression-expansion respiratory …

Lipid–protein and protein–protein interactions in the pulmonary surfactant system and their role in lung homeostasis

O Cañadas, B Olmeda, A Alonso… - International journal of …, 2020 - mdpi.com
Pulmonary surfactant is a lipid/protein complex synthesized by the alveolar epithelium and
secreted into the airspaces, where it coats and protects the large respiratory air–liquid …

Pulmonary surfactant and drug delivery: Focusing on the role of surfactant proteins

R Guagliardo, J Perez-Gil, S De Smedt… - Journal of Controlled …, 2018 - Elsevier
Pulmonary surfactant (PS) has been extensively studied because of its primary role in
mammalian breathing. The deposition of this surface-active material at the alveolar air-water …