Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Diffuse myocardial fibrosis resulting from the excessive deposition of collagen fibres through
the entire myocardium is encountered in a number of chronic cardiac diseases. This lesion …

Objectives The goal of this study was to evaluate the effect of empagliflozin, in addition to
optimal medical treatment, on epicardial adipose tissue (EAT), interstitial myocardial fibrosis …

The structure of connective tissues including cartilage, tendons, and ligaments as well as
many organs, like the skin, heart, liver, kidney, lungs, blood vessels, and bones, depend on …

More than 90% of patients with congenital heart disease (CHD) are nowadays surviving to
adulthood and adults account for over two-thirds of the contemporary CHD population in …

Cardiac fibrosis is a common pathological consequence of most myocardial diseases. It is
associated with the excessive accumulation of extracellular matrix proteins as well as …

Background and aims Scar tissue accumulation in organs is the underlying cause of many
fibrotic diseases. Due to the extensive array of organs affected, the long-term nature of …

Myocardial fibrosis refers to the pathological changes of heart structure and morphology
caused by various reasons of myocardial damage. It has become an important challenge in …

Heart failure (HF) is an extremely major health problem with gradually increasing incidence
in developed and developing countries. HF may lead to cardiac remodeling; thus, advanced …

Purpose Myocardial fibrosis (MF) is a factor of poor prognosis in systemic sclerosis (SSc).
Direct in-vivo visualization of fibroblast activation as early readout of MF has not been …