Amyotrophic lateral sclerosis (ALS) is the most common adult onset motor neuron disease
with no effective disease modifying therapies at present. Spinal cord degeneration is a …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by gradual loss of upper and lower motor neurons and their pathways, usually …

Clinical signs of upper motor neuron (UMN) involvement are an important component in
supporting the diagnosis of amyotrophic lateral sclerosis (ALS), but are often not easily …

Objective To evaluate MRI-based parameters as biomarkers of Amyotrophic Lateral
Sclerosis (ALS) progression. Methods Twenty-seven patients and 27 controls performed two …

The clinical diagnosis of amyotrophic lateral sclerosis (ALS) relies on determination of
progressive dysfunction of both cortical as well as spinal and bulbar motor neurons …

The main objective of this study was to utilize high field (7T) in vivo proton magnetic
resonance imaging to increase the ability to detect metabolite changes in people with ALS …

Background The pattern of lower motor neuron (LMN) degeneration in amyotrophic lateral
sclerosis (ALS), ie, dying-back (from the nerve ending to cell body) or dying-forward (from …

Our objective was to investigate spinal cord (SC) atrophy in amyotrophic lateral sclerosis
(ALS) patients, and to determine whether it correlates with clinical parameters. Forty-three …

Several quantitative magnetic resonance imaging (MRI) techniques have been proposed to
investigate microstructural tissue changes in amyotrophic lateral sclerosis (ALS) including …

Objective The stimulation of the masseteric nerve elicits a homonymous and a
heteronymous H reflex in the masseter muscle and in the temporalis one. The presence of …