Primary lateral sclerosis

S Marzoughi, G Pfeffer, N Cashman - Handbook of Clinical Neurology, 2023 - Elsevier
Like motor neuron diseases (MNDs) refer to a constellation of primarily sporadic
neurodegenerative diseases characterized by a progressive loss of upper and/or lower …

Cerebellar degeneration in primary lateral sclerosis: an under-recognized facet of PLS

E Finegan, WF Siah, S Li Hi Shing… - … Lateral Sclerosis and …, 2022 - Taylor & Francis
While primary lateral sclerosis (PLS) has traditionally been regarded as a pure upper motor
neuron disorder, recent clinical, neuroimaging and postmortem studies have confirmed …

Supra-and infra-tentorial degeneration patterns in primary lateral sclerosis: a multimodal longitudinal neuroradiology study

J Kleinerova, M Tahedl, EL Tan, S Delaney… - Journal of …, 2024 - Springer
Background Primary lateral sclerosis (PLS) is traditionally solely associated with progressive
upper motor neuron dysfunction manifesting in limb spasticity, gait impairment, bulbar …

Development of a thiostrepton-free system for stable production of PLD in Streptomyces lividans SBT5

J Wang, H Zhu, H Shang, B Guo, M Zhang… - Microbial Cell …, 2022 - Springer
Abstract Background Phospholipase D (PLD) is highly valuable in the food and medicine
industries, where it is used to convert low-cost phosphatidylcholine into high-value …

Better understanding the neurobiology of primary lateral sclerosis

PH Ozdinler, M Gautam, O Gozutok… - … Lateral Sclerosis and …, 2020 - Taylor & Francis
Primary lateral sclerosis (PLS) is a rare neurodegenerative disease characterized by
progressive degeneration of upper motor neurons (UMNs). Recent studies shed new light …

Primary lateral sclerosis natural history study–planning, designing, and early enrollment

H Mitsumoto, G Jang, I Lee, Z Simmons… - … Lateral Sclerosis and …, 2023 - Taylor & Francis
Abstract Introduction/Aims. Primary lateral sclerosis (PLS) is exceedingly rare and has been
an enigmatic disease. Recent progress has drastically changed this perception, with early …

Drug Repurposing for Primary Lateral Sclerosis: A Molecular Dynamic Study

SD Almeida, AK Pandey, M Mutahir, P Pai… - Current Trends in …, 2023 - books.google.com
Primary Lateral Sclerosis (PLS) is a slow and selective neurological disorder that affects the
central nervous system of adults. It leads to continuous muscle stiffness and subtle loss of …