To define and differentiate relevant aspects of blood–brain barrier transport and distribution
in order to aid research methodology in brain drug delivery. Pharmacokinetic parameters …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Purpose More than 15 years have passed since the first description of the unbound brain-to-
plasma partition coefficient (Kp, uu, brain) by Prof. Margareta Hammarlund-Udenaes, which …

In the past decade microdialysis has become a method of choice in the study of unbound
tissue concentrations of both endogenous and exogenous substances. Microdialysis has …

Microdialysis has contributed with very important knowledge to the understanding of target-
specific concentrations and their relationship to pharmacodynamic effects from a systems …

Concentrations of unbound drug in the interstitial fluid of the brain are not rapidly measured
in vivo. Therefore, measurement of total drug levels, ie, the amount of drug per gram of brain …

Despite enormous advances in CNS research, CNS disorders remain the world's leading
cause of disability. This accounts for more hospitalizations and prolonged care than almost …

The microdialysis technique was initially developed for monitoring neurotransmitters in
animals. In 1995 the technique was adopted to clinical use and bedside enzymatic analysis …

Our ultimate goal is to develop mechanism-based pharmacokinetic (PK)-pharmacodynamic
(PD) models to characterize and to predict CNS drug responses in both physiologic and …

The individual variability of opioid pharmacology suggests that the patients' genetic
disposition influences the response to opioids. Given the complexity of morphine …