Temporal lobe studies in motor neuron disease overwhelmingly focus on white matter
alterations and cortical grey matter atrophy. Reports on amygdala involvement are …

Amyotrophic lateral sclerosis (ALS) encompasses a heterogeneous group of phenotypes
with different progression rates, varying degree of extra-motor involvement and divergent …

Advances in neuroimaging, complementing histopathological insights, have established a
multi-system involvement of cerebral networks beyond the traditional neuromuscular …

Amyotrophic lateral sclerosis (ALS) is the most common adult onset motor neuron disease
with no effective disease modifying therapies at present. Spinal cord degeneration is a …

Background Brainstem pathology is a hallmark feature of ALS, yet most imaging studies
focus on cortical grey matter alterations and internal capsule white matter pathology …

Background: Magnetic resonance spectroscopy (MRS) in amyotrophic lateral sclerosis
(ALS) has been overwhelmingly applied to motor regions to date and our understanding of …

Primary lateral sclerosis (PLS) is classically considered a 'pure'upper motor neuron disorder.
Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of …

Post-polio syndrome (PPS) is a neurological condition that affects polio survivors decades
after their initial infection. Despite its high prevalence, the etiology of PPS remains elusive …

Background Primary lateral sclerosis (PLS) is a low incidence motor neuron disease which
carries a markedly better prognosis than amyotrophic lateral sclerosis (ALS). Despite …

Pathological crying and laughing (PCL) has significant quality-of-life implications in
amyotrophic lateral sclerosis (ALS); it can provoke restrictive life-style modifications and lead …