Imaging profiles from a longitudinal single-centre motor neuron disease study are
presented. A standardized T1-weighted MRI protocol was implemented to characterise …

Background MRI fluid‐attenuated inversion recovery (FLAIR) studies reported hyperintensity
in the corticospinal tract and corpus callosum of patients with amyotrophic lateral sclerosis …

The majority of imaging studies in ALS evaluate multiple MRI indices and conjecture
pathological interpretations without postmortem validation. Conversely, postmortem studies …

A prospective, standardised neuroimaging protocol was implemented to characterise mesial
temporal lobe pathology in amyotrophic lateral sclerosis, Alzheimer's disease and healthy …

Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease
characterized by loss of upper and lower motor neurons. There is a need for an imaging …

Motor neuron diseases (MNDs) encompass a range of progressive neurodegenerative
conditions with heterogeneous clinical presentations, disability profiles, prognosis, and age …

The neuroimaging literature of motor neuron diseases is dominated by studies in ALS (1, 2).
There is a relative paucity of quantitative MRI studies in other motor neuron diseases despite …

The present dissertation proposes a standardized assessment tool for meaningful
interpretation of individual patients' MRI data which may be used to infer on atrophy (or …

Research in ALS has gained unprecedented momentum in recent years fueled by important
conceptual developments, establishment of international consortia, breakthrough genetic …

(FTLD) has been refined by robust computational imaging studies in recent years. This has
led to the characterisation of phenotype-1-16 and genotypeassociated 17-23 patterns of …