In the past two decades, structural and functional neuroimaging findings have greatly
modified longstanding notions regarding the pathophysiology of amyotrophic lateral …

Although the past two decades have produced exciting discoveries in the genetics and
pathology of amyotrophic lateral sclerosis (ALS), progress in developing an effective therapy …

MRI has emerged as one of several urgently needed candidate disease progression
biomarkers for the neurodegenerative disorder amyotrophic lateral sclerosis (ALS), not least …

Objective To evaluate progressive white matter (WM) degeneration in amyotrophic lateral
sclerosis (ALS). Methods Sixty-six patients with ALS and 43 healthy controls were enrolled …

Background Corticospinal tract (CST) degeneration and cortical atrophy are consistent
features of amyotrophic lateral sclerosis (ALS). We hypothesised that neurite orientation …

Diffusion tensor imaging (DTI) allows the in vivo imaging of pathological white matter
alterations, either with unbiased voxel-wise or hypothesis-guided tract-based analysis …

Amyotrophic lateral sclerosis (ALS) encompasses a heterogeneous group of phenotypes
with different progression rates, varying degree of extra-motor involvement and divergent …

Background: Cross-sectional imaging studies offer valuable pathological insights into the
neurodegenerative changes of amyotrophic lateral sclerosis. However, clinical trials urgently …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative, clinically
heterogeneous syndrome pathologically overlapping with frontotemporal dementia. To date …

Electrical impedance myography (EIM), a non-invasive, electrophysiological technique, has
preliminarily shown value as an ALS biomarker. Here we perform a multicenter study to …