Although we acknowledge the academic achievements of large descriptive studies, an
unmet priority of neuroimaging in MND is the development of robust diagnostic, prognostic …

Background Bulbar dysfunction is a cardinal feature of ALS with important quality of life and
management implications. The objective of this study is the longitudinal evaluation of a large …

Disease heterogeneity in amyotrophic lateral sclerosis poses a substantial challenge in drug
development. Categorization based on clinical features alone can help us predict the …

Introduction Pseudobulbar affect (PBA) is a distressing symptom of a multitude of
neurological conditions affecting patients with a rage of neuroinflammatory, neurovascular …

Background Primary lateral sclerosis (PLS) is traditionally solely associated with progressive
upper motor neuron dysfunction manifesting in limb spasticity, gait impairment, bulbar …

Background Primary lateral sclerosis (PLS) is traditionally regarded as a pure upper motor
neuron disorder, but recent cases series have highlighted cognitive deficits in executive and …

Introduction Primary lateral sclerosis (PLS) is a rare, adult-onset and slowly progressive
motor neuron disorder whose clinical core is characterized by upper motor neuron (UMN) …

Primary lateral sclerosis (PLS) is a rare neurodegenerative disorder which causes the
selective deterioration of the upper motor neurons (UMNs), sparing the lower motor neuron …

Background Language deficits are cardinal manifestations of some frontotemporal dementia
(FTD) phenotypes and also increasingly recognized in sporadic and familial amyotrophic …

Advances in clinical care and recent research achievements: Primary lateral sclerosis (PLS)
has traditionally been regarded as a pure upper motor neuron condition, a view perpetuated …