Brain tumors are one of the most formidable diseases of mankind. They have only a fair to
poor prognosis and high relapse rate. One of the major causes of extreme difficulty in brain …

Recently, one of the key trends in the pharmaceutical industry has been the integration of
what have traditionally been considered 'development'activities into the early phases of drug …

The blood–brain barrier (BBB) serves as a protective mechanism for the brain by preventing
entry of potentially harmful substances from free access to the central nervous system …

Drug delivery to brain tumors has been a controversial subject. Some believe the blood-
brain barrier is not important, while others believe it is the major obstacle in treatment and …

To define and differentiate relevant aspects of blood–brain barrier transport and distribution
in order to aid research methodology in brain drug delivery. Pharmacokinetic parameters …

Diffusion plays a crucial role in brain function. The spaces between cells can be likened to
the water phase of a foam and many substances move within this complicated region …

Plasma protein binding of drugs is a well-recognised phenomena, but it is only recently that
the implications for drug action in vivo have been fully appreciated. Plasma proteins, by …

Glioblastoma multiforme (GBM) is the most aggressive and lethal type of brain tumor. Both
therapeutic resistance and restricted permeation of drugs across the blood–brain barrier …

The blood-brain barrier (BBB) is a dynamic interface between the blood and the brain. It
eliminates (toxic) substances from the endothelial compartment and supplies the brain with …

Brain delivery is a broad research area, the outcomes of which are far hindered by the
limited permeability of the blood–brain barrier (BBB). Over the last century, research has …