Opiates are among the oldest medications available to manage a number of medical
problems. Although pain is the current focus, early use initially focused upon the treatment of …

Many oxidation–reduction (redox) enzymes, particularly oxygenases, have roles in reactions
that make and break C–C bonds. The list includes cytochrome P450 and other heme-based …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Love is a complex neurobiological phenomenon, relying on trust, belief, pleasure and
reward activities within the brain, ie, limbic processes. These processes critically involve …

Abstract BACKGROUND AND OBJECTIVE: Stress is natural and belongs to life itself. To
sustain it and even grow with it biology invented different mechanisms, since stress …

An efficient divergent synthetic strategy for the synthesis of the opiate and amaryllidaceae
alkaloids emerges by employing a Pd-catalyzed asymmetric allylic alkylation (AAA) to set …

Gene duplications drive the recruitment of genes for secondary metabolism. Gene copies
are gradually modified to create genes with specificities and expression patterns adapted to …

Opiate analgesics are widely used and abused drugs. Individual differences in opiate
sensitivity can hamper effective pain treatments and increase risks of drug abuse. Although …

We describe novel chemoenzymatic routes to (S)-benzylisoquinoline and (S)-
tetrahydroprotoberberine alkaloids using the enzymes transaminase (TAm) and …

Background The classic paradigm of heterotrimeric G-protein signaling describes a
heptahelical, membrane-spanning G-protein coupled receptor that physically interacts with …