Diffusion MRI enabled in vivo microstructural imaging of the fiber tracts in the brain resulting
in its application in a wide range of settings, including in neurological and neurosurgical …

Here we introduce the concept of the local connectome: the degree of connectivity between
adjacent voxels within a white matter fascicle defined by the density of the diffusing spins …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no effective
treatment or cure. ALS is characterized by the death of lower motor neurons (LMNs) in the …

Diffusion MRI tractography has been used to map the axonal structure of the human brain,
but its ability to detect neuronal injury is yet to be explored. Here we report differential …

Objective Neuropathological studies in amyotrophic lateral sclerosis (ALS) have shown a
dissemination in a regional sequence in four anatomically defined patterns. The aim of this …

Background Major depressive disorder (MDD) is a debilitating disorder characterized by
widespread brain abnormalities. The literature is mixed as to whether or not white matter …

Purpose: To determine if clinical and histopathologic findings were present in the eyes of
patients with amyotrophic lateral sclerosis (ALS) and explore correlations to an animal …

Introduction: In the last decade, multiparametric magnetic resonance imaging (MRI) has
achieved tremendous advances in applications to amyotrophic lateral sclerosis (ALS) to …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a complex neurodegenerative disorder that
may have anterior visual pathway involvement. In this study, we compare the macular …

Objective: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative process
affecting upper and lower motor neurons as well as non-motor systems. In this study …