The suicide death toll is alarmingly high, outnumbering deaths from war and homicide
worldwide (1). Many factors contribute to suicide death, making it difficult to prevent because …

Buprenorphine is a Schedule III opioid analgesic with unique pharmacodynamic and
pharmacokinetic properties that may be preferable to those of Schedule II full μ-opioid …

Objective: Suicidal ideation and behavior currently have no quick-acting pharmacological
treatments that are suitable for independent outpatient use. Suicidality is linked to mental …

Despite proven clinical utility, buprenorphine has not been used widely for the treatment of
chronic pain. Questions about “ceiling effect” or bell-shaped curve observed for analgesia in …

Background In response to the opioid epidemic and new guidelines, many patients on high-
dose long term opioid therapy (LTOT) for chronic pain are getting tapered off opioids. As a …

Purpose Buprenorphine is an opioid partial agonist used to treat opioid use disorder. While
several policy changes have attempted to increase buprenorphine availability, access …

Clinical studies demonstrate that buprenorphine is a pharmacologic agent that can be used
for the treatment of various types of painful conditions. This study investigated the efficacy of …

Background Chronic pain is associated with decreased quality of life and is one of the most
common reasons adults seek medical care, making treatment imperative for many aspects of …

Introduction: Pain relief remains a major public health challenge. The most efficient available
painkillers are opioids targeting the mu opioid receptor (MOR). MORs are expressed in the …

The risk of suicide in psychiatric hospitals is 50 times higher than in the general population,
despite patient safety being a priority for any hospital. However, to date, due to the …