Diagnostic approach to atypical parkinsonian syndromes

NR McFarland - CONTINUUM: Lifelong Learning in Neurology, 2016 - journals.lww.com
Abstract Purpose of Review: Although increasingly recognized, atypical parkinsonian
syndromes remain challenging to diagnose and are underrecognized due to overlap with …

Pseudobulbar affect: prevalence and management

A Ahmed, Z Simmons - Therapeutics and Clinical Risk …, 2013 - Taylor & Francis
Pseudobulbar affect (PBA) may occur in association with a variety of neurological diseases,
and so may be encountered in the setting of amyotrophic lateral sclerosis, extrapyramidal …

Dextromethorphan/quinidine: in pseudobulbar affect

KP Garnock-Jones - CNS drugs, 2011 - Springer
Pseudobulbar affect is characterized by uncontrollable, inappropriate laughing and/or crying
that is either unrelated or out of proportion to the emotions felt by the patient and occurs in …

Pseudobulbar affect: the spectrum of clinical presentations, etiologies and treatments

A Miller, H Pratt, RB Schiffer - Expert Review of Neurotherapeutics, 2011 - Taylor & Francis
Pseudobulbar affect (PBA) consists of uncontrollable outbursts of laughter or crying
inappropriate to the patient's external circumstances and incongruent with the patient's …

Pseudobulbar affect: an under-recognized and under-treated neurological disorder

SS Work, JA Colamonico, WG Bradley, RE Kaye - Advances in therapy, 2011 - Springer
Introduction Pseudobulbar affect (PBA) is a neurologic syndrome of emotional affect
disinhibition, characterized by uncontrollable, exaggerated, and often inappropriate …

Toward a more precise, clinically—informed pathophysiology of pathological laughing and crying

EC Lauterbach, JL Cummings… - … & biobehavioral reviews, 2013 - Elsevier
Involuntary emotional expression disorder (IEED) includes the syndromes of pathological
laughing and crying (PLC) and emotional lability (EL). Review of the lesion, epilepsy, and …

PRISM: a novel research tool to assess the prevalence of pseudobulbar affect symptoms across neurological conditions

BR Brooks, D Crumpacker, J Fellus, D Kantor… - PloS one, 2013 - journals.plos.org
Background Pseudobulbar affect (PBA) is a neurological condition characterized by
involuntary, sudden, and frequent episodes of laughing and/or crying, which can be socially …

Pseudobulbar affect: burden of illness in the USA

J Colamonico, A Formella, W Bradley - Advances in therapy, 2012 - Springer
Introduction Pseudobulbar affect (PBA) is characterized by involuntary and uncontrollable
laughing and/or crying episodes, occurring secondary to neurological disease or injury. The …

Recognizing atypical Parkinsonisms:“Red Flags” and therapeutic approaches

NR McFarland, CW Hess - Seminars in neurology, 2017 - thieme-connect.com
The overlap of signs and symptoms between Parkinson's disease and the atypical
parkinsonian syndromes, such as progressive supranuclear palsy, multiple system atrophy …

Assessment of use of combined dextromethorphan and quinidine in patients with dementia or Parkinson disease after US Food and Drug Administration approval for …

M Fralick, CA Sacks, AS Kesselheim - JAMA Internal Medicine, 2019 - jamanetwork.com
Importance In 2010, the US Food and Drug Administration (FDA) approved a combination of
dextromethorphan hydrobromide and quinidine sulfate for the treatment of pseudobulbar …